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• W924980902 abstract "Theories have proposed that, in sensory cortices, learning can enhance top-down modulation by higher brain areas while reducing bottom-up sensory drives. To address circuit mechanisms underlying this process, we examined the activity of layer 2/3 (L2/3) excitatory neurons in the mouse primary visual cortex (V1) as well as L4 excitatory neurons, the main bottom-up source, and long-range top-down projections from the retrosplenial cortex (RSC) during associative learning over days using chronic two-photon calcium imaging. During learning, L4 responses gradually weakened, whereas RSC inputs became stronger. Furthermore, L2/3 acquired a ramp-up response temporal profile, potentially encoding the timing of the associated event, which coincided with a similar change in RSC inputs. Learning also reduced the activity of somatostatin-expressing inhibitory neurons (SOM-INs) in V1 that could potentially gate top-down inputs. Finally, RSC inactivation or SOM-IN activation was sufficient to partially reverse the learning-induced changes in L2/3. Together, these results reveal a learning-dependent dynamic shift in the balance between bottom-up and top-down information streams and uncover a role of SOM-INs in controlling this process." @default.
• W924980902 created "2016-06-24" @default.
• W924980902 creator A5001630876 @default.
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• W924980902 date "2015-07-13" @default.
• W924980902 modified "2023-10-18" @default.
• W924980902 title "Learning enhances the relative impact of top-down processing in the visual cortex" @default.
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• W924980902 doi "https://doi.org/10.1038/nn.4061" @default.
• W924980902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4523093" @default.
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