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- W92504502 abstract "Abstract Although it had long been known that steroids secreted by the adrenal cortex exerted important inhibitory effects on cells of the immune system, the concept of bidirectional communication between the immune system and the nervous system became widely accepted when it was recognized that activation of the hypothalamo–pituitary–adrenocortical (HPA) axis associated with stress was not the only effect the central nervous system (CNS) exerted on the immune system, and that factors secreted by immune cells could have important effects on the CNS. Activation of the HPA axis results in elevation of circulating concentrations of corticosteroids which drive them from the thymus and spleen into the periphery and inhibit various immune activities. The immune system can also signal the CNS regarding the presence of foreign antigens in peripheral organs. A key finding was that interleukin-1 (IL-1) was a potent stimulator of HPA axis activity. The major known mechanism by which the immune system signals the brain involves cytokines, which are the major chemical messengers within the immune system. Certain other cytokines [e.g, IL-6, IL-10, and tumor necrosis factor-α (TNF-α)] can activate the HPA axis. Cytokines exert their effects on the CNS via afferents of nerves, such as the vagus, although some direct actions of circulating cytokines on the nervous system may also occur. Immune cells can penetrate the brain under some circumstances. The CNS in turn can influence immune function via the autonomic nervous system and various hormones secreted by the pituitary, the adrenal, and other endocrine organs. Cytokines (especially IL-1) can alter the activity of neurotransmitters in the CNS, most notably norepinephrine and corticotropin-releasing factor (CRF), and can have important effects on behavior." @default.
- W92504502 created "2016-06-24" @default.
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- W92504502 date "2007-01-01" @default.
- W92504502 modified "2023-10-01" @default.
- W92504502 title "The HPA Axis and the Immune System" @default.
- W92504502 cites W1505944302 @default.
- W92504502 cites W1522773084 @default.
- W92504502 cites W1577588217 @default.
- W92504502 cites W1645475532 @default.
- W92504502 cites W1966449090 @default.
- W92504502 cites W1968362347 @default.
- W92504502 cites W1970833034 @default.
- W92504502 cites W1971301427 @default.
- W92504502 cites W1971589629 @default.
- W92504502 cites W1975918022 @default.
- W92504502 cites W1976030449 @default.
- W92504502 cites W1977918131 @default.
- W92504502 cites W1978051898 @default.
- W92504502 cites W1979827819 @default.
- W92504502 cites W1982210763 @default.
- W92504502 cites W1983110579 @default.
- W92504502 cites W1988951832 @default.
- W92504502 cites W1991052041 @default.
- W92504502 cites W1991704512 @default.
- W92504502 cites W1993372469 @default.
- W92504502 cites W1993537924 @default.
- W92504502 cites W1993983321 @default.
- W92504502 cites W1998086688 @default.
- W92504502 cites W1998809543 @default.
- W92504502 cites W1999311683 @default.
- W92504502 cites W2000956334 @default.
- W92504502 cites W2006587144 @default.
- W92504502 cites W2019339895 @default.
- W92504502 cites W2019965219 @default.
- W92504502 cites W2022263551 @default.
- W92504502 cites W2026825495 @default.
- W92504502 cites W2027083489 @default.
- W92504502 cites W2028268181 @default.
- W92504502 cites W2029027714 @default.
- W92504502 cites W2029761100 @default.
- W92504502 cites W2031333613 @default.
- W92504502 cites W2035072797 @default.
- W92504502 cites W2036062598 @default.
- W92504502 cites W2038126903 @default.
- W92504502 cites W2038803905 @default.
- W92504502 cites W2038983763 @default.
- W92504502 cites W2040596530 @default.
- W92504502 cites W2042904026 @default.
- W92504502 cites W2044835159 @default.
- W92504502 cites W2051172489 @default.
- W92504502 cites W2052605776 @default.
- W92504502 cites W2052912399 @default.
- W92504502 cites W2057688664 @default.
- W92504502 cites W2058358711 @default.
- W92504502 cites W2059108568 @default.
- W92504502 cites W2061026694 @default.
- W92504502 cites W2061512117 @default.
- W92504502 cites W2063026836 @default.
- W92504502 cites W2063579231 @default.
- W92504502 cites W2072170892 @default.
- W92504502 cites W2072386163 @default.
- W92504502 cites W2073737942 @default.
- W92504502 cites W2079912778 @default.
- W92504502 cites W2082497253 @default.
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- W92504502 cites W2095488297 @default.
- W92504502 cites W2095620291 @default.
- W92504502 cites W20984170 @default.
- W92504502 cites W2120658378 @default.
- W92504502 cites W2123574874 @default.
- W92504502 cites W2141020380 @default.
- W92504502 cites W2145056112 @default.
- W92504502 cites W2145890122 @default.
- W92504502 cites W2148930555 @default.
- W92504502 cites W2165976043 @default.
- W92504502 cites W4233859112 @default.
- W92504502 cites W4237601915 @default.
- W92504502 cites W4244933369 @default.
- W92504502 cites W568417880 @default.
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- W92504502 doi "https://doi.org/10.1016/s1567-7443(07)00201-3" @default.
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