Matches in SemOpenAlex for { <https://semopenalex.org/work/W92527897> ?p ?o ?g. }
- W92527897 endingPage "780" @default.
- W92527897 startingPage "773" @default.
- W92527897 abstract "Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific receptors and exert distinct functions. It is crucial to understand how exercise affects crucial steps in the BDNF processing and signaling to evaluate therapeutic applications. We found that 7 days of voluntary exercise increased both pro and mature BDNF in the rat hippocampus. Exercise also increased the activity of tissue-type plasminogen activator (tPA), a serine proteinase shown to facilitate proBDNF cleavage into mBDNF. The blockade of tPA activity reduced the exercise effects on proBDNF and mBDNF. The tPA blocking also inhibited the activation of TrkB receptor, and the TrkB signaling downstream effectors phospho-ERK, phospho-Akt, and phospho-CaMKII. The blocking of tPA also counteracted the effects of exercise on the plasticity markers phospho-synapsin I and growth-associated protein 43 (GAP-43). These results indicate that the effects of exercise on hippocampal plasticity are dependent on BDNF processing and subsequent TrkB signaling, with important implications for neuronal function." @default.
- W92527897 created "2016-06-24" @default.
- W92527897 creator A5038362399 @default.
- W92527897 creator A5060552570 @default.
- W92527897 creator A5074516453 @default.
- W92527897 date "2011-09-01" @default.
- W92527897 modified "2023-10-10" @default.
- W92527897 title "Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing" @default.
- W92527897 cites W1480941661 @default.
- W92527897 cites W1494500191 @default.
- W92527897 cites W1505414983 @default.
- W92527897 cites W1528782632 @default.
- W92527897 cites W1554351458 @default.
- W92527897 cites W1562675703 @default.
- W92527897 cites W1588547191 @default.
- W92527897 cites W1589328203 @default.
- W92527897 cites W170973748 @default.
- W92527897 cites W1907075860 @default.
- W92527897 cites W1921580387 @default.
- W92527897 cites W1965505012 @default.
- W92527897 cites W1966901093 @default.
- W92527897 cites W1977573757 @default.
- W92527897 cites W1979043927 @default.
- W92527897 cites W1988258938 @default.
- W92527897 cites W1989665355 @default.
- W92527897 cites W1992790917 @default.
- W92527897 cites W1993870556 @default.
- W92527897 cites W1994497884 @default.
- W92527897 cites W1995485524 @default.
- W92527897 cites W2001079770 @default.
- W92527897 cites W2004107819 @default.
- W92527897 cites W2010694996 @default.
- W92527897 cites W2012655459 @default.
- W92527897 cites W2013963733 @default.
- W92527897 cites W2027973075 @default.
- W92527897 cites W2036960054 @default.
- W92527897 cites W2038145816 @default.
- W92527897 cites W2047159816 @default.
- W92527897 cites W2049776725 @default.
- W92527897 cites W2054496958 @default.
- W92527897 cites W2055667548 @default.
- W92527897 cites W2062305670 @default.
- W92527897 cites W2062712759 @default.
- W92527897 cites W2075450921 @default.
- W92527897 cites W2086970243 @default.
- W92527897 cites W2087090756 @default.
- W92527897 cites W2088754913 @default.
- W92527897 cites W2095342717 @default.
- W92527897 cites W2119757776 @default.
- W92527897 cites W2122020125 @default.
- W92527897 cites W2131865492 @default.
- W92527897 cites W2138182618 @default.
- W92527897 cites W2140273147 @default.
- W92527897 cites W2140922960 @default.
- W92527897 cites W2142925967 @default.
- W92527897 cites W2152653512 @default.
- W92527897 doi "https://doi.org/10.1016/j.neuroscience.2011.06.032" @default.
- W92527897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3225196" @default.
- W92527897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21756980" @default.
- W92527897 hasPublicationYear "2011" @default.
- W92527897 type Work @default.
- W92527897 sameAs 92527897 @default.
- W92527897 citedByCount "115" @default.
- W92527897 countsByYear W925278972012 @default.
- W92527897 countsByYear W925278972013 @default.
- W92527897 countsByYear W925278972014 @default.
- W92527897 countsByYear W925278972015 @default.
- W92527897 countsByYear W925278972016 @default.
- W92527897 countsByYear W925278972017 @default.
- W92527897 countsByYear W925278972018 @default.
- W92527897 countsByYear W925278972019 @default.
- W92527897 countsByYear W925278972020 @default.
- W92527897 countsByYear W925278972021 @default.
- W92527897 countsByYear W925278972022 @default.
- W92527897 countsByYear W925278972023 @default.
- W92527897 crossrefType "journal-article" @default.
- W92527897 hasAuthorship W92527897A5038362399 @default.
- W92527897 hasAuthorship W92527897A5060552570 @default.
- W92527897 hasAuthorship W92527897A5074516453 @default.
- W92527897 hasBestOaLocation W925278972 @default.
- W92527897 hasConcept C126322002 @default.
- W92527897 hasConcept C130316041 @default.
- W92527897 hasConcept C134139212 @default.
- W92527897 hasConcept C148762608 @default.
- W92527897 hasConcept C148785051 @default.
- W92527897 hasConcept C160539049 @default.
- W92527897 hasConcept C169760540 @default.
- W92527897 hasConcept C170493617 @default.
- W92527897 hasConcept C2778790584 @default.
- W92527897 hasConcept C41625074 @default.
- W92527897 hasConcept C47611674 @default.
- W92527897 hasConcept C50493954 @default.
- W92527897 hasConcept C55493867 @default.
- W92527897 hasConcept C71924100 @default.
- W92527897 hasConcept C86803240 @default.
- W92527897 hasConcept C92020748 @default.
- W92527897 hasConcept C97124661 @default.
- W92527897 hasConceptScore W92527897C126322002 @default.