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- W925633768 abstract "目的：探讨IL-37对肺癌A549细胞增殖及E-cadherin（E-cad）转录表达的影响。方法：将IL-37过表达载体转染肺癌A549细胞，采用Real time PCR检测IL-37及E-cadherin的mRNA表达，Western blot检测蛋白表达，CCK-8法检测A549细胞增殖。结果：在转录水平，IL-37组mRNA表达较NC组升高约200倍；在蛋白水平，NC组A549细胞中几乎未见IL-37蛋白表达，IL-37组则检测到明显的IL-37蛋白，显示IL-37重组质粒成功转染A549细胞。IL-37组与NC组相比，E-cad的mRNA水平升高约20%。在对A549细胞的增殖影响方面，与NC组相比，在24h，48h，72h，IL-37组细胞增殖抑制率约为15.6%，29.2%，28.1%。结论：新型抗炎因子IL-37可抑制A549细胞增殖并上调E-cad表达。" @default.
- W925633768 created "2016-06-24" @default.
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- W925633768 date "2014-01-01" @default.
- W925633768 modified "2023-09-23" @default.
- W925633768 title "新型抗炎因子IL-37对肺癌A549细胞增殖及E-cadherin转录表达的影响" @default.
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