Matches in SemOpenAlex for { <https://semopenalex.org/work/W925871307> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W925871307 endingPage "36" @default.
- W925871307 startingPage "2829" @default.
- W925871307 abstract "The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established.We performed immunohistochemical staining of p53, P-gp and GST-pi using transbronchial biopsy specimens obtained from previously untreated NSCLC patients.Of 45 patients examined, p53 immunostaining was positive in 18 (40%) patients. The objective response rate by cisplatin (CDDP)-based chemotherapy was significantly lower in patients with p53-positive tumors compared to those with p53-negative tumors (22% versus 59%, p = 0.0143). Survival of the patients with p53-positive tumors was significantly shorter than those with p53-negative tumors (median survival time: 4.6 months versus 12.2 months, p = 0.011), which was confirmed by the multivariate analysis (p = 0.0243). However, P-gp and GST-pi showed no significant relationship with either response rate or survival in patients with unresectable NSCLC receiving CDDP-based chemotherapy.p53 alteration is an independent and significant indicator to predict unfavorable prognosis in patients with unresectable NSCLC." @default.
- W925871307 created "2016-06-24" @default.
- W925871307 creator A5001897650 @default.
- W925871307 creator A5004153390 @default.
- W925871307 creator A5006348007 @default.
- W925871307 creator A5007888883 @default.
- W925871307 creator A5034664727 @default.
- W925871307 creator A5039723911 @default.
- W925871307 creator A5061995886 @default.
- W925871307 creator A5066700160 @default.
- W925871307 creator A5078907905 @default.
- W925871307 creator A5081173458 @default.
- W925871307 date "2003-08-21" @default.
- W925871307 modified "2023-09-27" @default.
- W925871307 title "Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer." @default.
- W925871307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12926120" @default.
- W925871307 hasPublicationYear "2003" @default.
- W925871307 type Work @default.
- W925871307 sameAs 925871307 @default.
- W925871307 citedByCount "8" @default.
- W925871307 countsByYear W9258713072012 @default.
- W925871307 countsByYear W9258713072014 @default.
- W925871307 countsByYear W9258713072017 @default.
- W925871307 crossrefType "journal-article" @default.
- W925871307 hasAuthorship W925871307A5001897650 @default.
- W925871307 hasAuthorship W925871307A5004153390 @default.
- W925871307 hasAuthorship W925871307A5006348007 @default.
- W925871307 hasAuthorship W925871307A5007888883 @default.
- W925871307 hasAuthorship W925871307A5034664727 @default.
- W925871307 hasAuthorship W925871307A5039723911 @default.
- W925871307 hasAuthorship W925871307A5061995886 @default.
- W925871307 hasAuthorship W925871307A5066700160 @default.
- W925871307 hasAuthorship W925871307A5078907905 @default.
- W925871307 hasAuthorship W925871307A5081173458 @default.
- W925871307 hasConcept C126322002 @default.
- W925871307 hasConcept C142724271 @default.
- W925871307 hasConcept C143998085 @default.
- W925871307 hasConcept C204232928 @default.
- W925871307 hasConcept C2776256026 @default.
- W925871307 hasConcept C2776283816 @default.
- W925871307 hasConcept C2776694085 @default.
- W925871307 hasConcept C2777546739 @default.
- W925871307 hasConcept C2778239845 @default.
- W925871307 hasConcept C4224716 @default.
- W925871307 hasConcept C71924100 @default.
- W925871307 hasConcept C90924648 @default.
- W925871307 hasConceptScore W925871307C126322002 @default.
- W925871307 hasConceptScore W925871307C142724271 @default.
- W925871307 hasConceptScore W925871307C143998085 @default.
- W925871307 hasConceptScore W925871307C204232928 @default.
- W925871307 hasConceptScore W925871307C2776256026 @default.
- W925871307 hasConceptScore W925871307C2776283816 @default.
- W925871307 hasConceptScore W925871307C2776694085 @default.
- W925871307 hasConceptScore W925871307C2777546739 @default.
- W925871307 hasConceptScore W925871307C2778239845 @default.
- W925871307 hasConceptScore W925871307C4224716 @default.
- W925871307 hasConceptScore W925871307C71924100 @default.
- W925871307 hasConceptScore W925871307C90924648 @default.
- W925871307 hasIssue "3C" @default.
- W925871307 hasLocation W9258713071 @default.
- W925871307 hasOpenAccess W925871307 @default.
- W925871307 hasPrimaryLocation W9258713071 @default.
- W925871307 hasRelatedWork W2083033314 @default.
- W925871307 hasRelatedWork W2124411053 @default.
- W925871307 hasRelatedWork W2132646345 @default.
- W925871307 hasRelatedWork W2273140211 @default.
- W925871307 hasRelatedWork W2354229318 @default.
- W925871307 hasRelatedWork W2361287035 @default.
- W925871307 hasRelatedWork W2381460883 @default.
- W925871307 hasRelatedWork W2796957233 @default.
- W925871307 hasRelatedWork W3030577889 @default.
- W925871307 hasRelatedWork W3155373832 @default.
- W925871307 hasVolume "23" @default.
- W925871307 isParatext "false" @default.
- W925871307 isRetracted "false" @default.
- W925871307 magId "925871307" @default.
- W925871307 workType "article" @default.