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- W9258725 abstract "Objective High altitude, long-term hypoxia (LTH) is associated with a number of changes in pre- and post-junctional signaling in both fetal and adult cerebrovasculature. Because PKC and downstream pathways play a key role in Ca2+ sensitization of vascular contraction, and are less abundant in fetus, we tested the hypothesis that LTH alters PKC activation pathways differently in the fetus, as compared to the adult. Methods In cerebral arteries we quantified both total and activated (phosphorylated) PKC, ERK1/2, caldesmon, Rho A, CPI-17, and myosin light chain20 (MLC20), and PDBu- (PKC agonist) induced contractions and their responses to blockade of ERKs (U-0126) or Rho kinase (Y-27632). Results In adult cerebral arteries, LTH acclimatization was associated with significant decreases in total and activated PKC, with increases in activated ERK1/2, CPI-17, and MLC20 and its kinase. In contrast, in fetal arteries LTH increased PKC expression and increased ERK1/2 activation, with no change in caldesmon, Rho A, CPI-17, or MLC20. Conclusions In adult cerebral arteries, acclimatization to LTH is associated with significant up- or down-regulation of a number of elements of the PKC-dependent Ca2+ sensitization pathway. In contrast, acclimatization to LTH in the fetus is associated with relatively minor changes in the Ca2+ sensitization pathway. (Supported by USPHS HD 31226)" @default.
- W9258725 created "2016-06-24" @default.
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- W9258725 date "2009-04-01" @default.
- W9258725 modified "2023-09-23" @default.
- W9258725 title "High altitude acclimatization responses in cerebral artery PKC‐dependent signaling pathway proteins: Changes with development" @default.
- W9258725 doi "https://doi.org/10.1096/fasebj.23.1_supplement.616.14" @default.
- W9258725 hasPublicationYear "2009" @default.
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