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- W92590667 abstract "This chapter presents comments on experiments used to distinguish between altered self and dual recognition. The anti-idiotype experiments are difficult to reconcile with altered self and impossible to reconcile with a different and more restricted germ line repertoire for T cells compared to B cells. If the latter is true (common V gene repertoire), then the large clone size reactive to allogeneic cells is difficult to reconcile with altered self. A new model of T cell education based on a common, unrestricted repertoire for T and B cells and strict dual recognition for all T cells, including those recognizing allogeneic cells, is proposed. The test of the theory is to determine if the bulk of the dividing cells of the thymus have receptors for H and X, that is, self-antigens." @default.
- W92590667 created "2016-06-24" @default.
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- W92590667 date "1980-01-01" @default.
- W92590667 modified "2023-09-26" @default.
- W92590667 title "ARE THERE DECISIVE EXPERIMENTS DISTINGUISHING ALTERED SELF AND DUAL RECOGNITION?" @default.
- W92590667 doi "https://doi.org/10.1016/b978-0-12-637140-6.50041-3" @default.
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