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- W92613672 abstract "The complement system is an ancient element of innate immunity present at progressively more evolved forms in the blood or lymph of all vertebrates studied and in at least some invertebrate species (Nonaka 1998). It provides one of the best examples of an effective first line of host defense system. Complement can recognize conserved repetitive structural elements important for the survival of pathogens and therefore shared by large groups of them. Recognition leads to the activation of the system and elimination of the pathogens either by direct killing or by opsonophagocytosis and intracellular killing. In parallel, complement also provides signals to adaptive immunity instructing it to respond vigorously against pathogens (Carroll 1998; Fearon 1998). Furthermore, through its ability to discriminate between free and antigen-bound immunoglobulins, complement serves as an effector arm of adaptive humoral immunity leading to elimination of pathogens recognized by specific antibodies. Finally, complement appears to have a special relationship with natural antibodies depending on them for recognition of important pathogens and in turn providing signals for clonal selection and expansion of CD5+ B-1 cells that produce natural antibodies (Carroll and Prodeus 1998)." @default.
- W92613672 created "2016-06-24" @default.
- W92613672 creator A5038250062 @default.
- W92613672 date "2002-01-01" @default.
- W92613672 modified "2023-10-16" @default.
- W92613672 title "The Role of Complement in Innate and Adaptive Immunity" @default.
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- W92613672 doi "https://doi.org/10.1007/978-3-662-04700-2_4" @default.
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