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• W92634484 abstract "Melt extrusion is increasingly popular in pharmaceutical applications due to a host of benefits it confers. However, due to the technology’s relatively more recent introduction into pharmaceutical processing, challenges in the development of extrusion based formulations/processes as well as the strategies to resolve them may not be as widely understood as the benefits. This chapter illustrates strategies to resolve challenges in the development of extruder-based formulations/processes using case studies on poorly soluble drugs (a) that are thermosensitive, (b) that exhibit high, or (c) low melting points and glass transition temperatures. Additional case studies also illustrate strategies to enable (d) very high drug loads of up to 95 % for highly water-soluble drugs and (e) moisture-sensitive drugs. As these case studies represent a small part of the expanding universe of melt extrusion applications and a ready-to-use solutions that address the challenges become increasingly available, it is fair to expect that twin-screw extrusion will continue to emerge as a powerful technology solution to a number of pharmaceutical formulation/process challenges." @default.
• W92634484 created "2016-06-24" @default.
• W92634484 creator A5054877790 @default.
• W92634484 date "2013-01-01" @default.
• W92634484 modified "2023-10-12" @default.
• W92634484 title "Formulation, Bioavailability, and Manufacturing Process Enhancement: Novel Applications of Melt Extrusion in Enabling Product Development" @default.
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• W92634484 doi "https://doi.org/10.1007/978-1-4614-8432-5_14" @default.
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