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- W926886952 abstract "Polysaccharides possess great potential as building blocks in the development of drug delivery vehicles. This can be attributed to their outstanding virtues, such as biocompatibility,biodegradability, and possession of a plenty of functional groups. Their chemical flexibilityallows for the modification of polysaccharides, leading to diverse functionalities that are valuable in biomedical applications. A promising functionality is stimuli-responsiveness that results in a change of physical or chemical properties of polysaccharide-based nanocarriers inresponse to an environmental change, such as pH, temperature, and light. Herein, recent strategies to develop polysaccharide-based nanomaterials for biomedical application are mapped out. Furthermore, using carboxymethyl cellulose (CMC) as a promising pH-sensitivepolysaccharide, two types of stimuli-responsive polysaccharide-based nanomaterials were developed and evaluated as potential tumor targeting drug delivery nanocarriers.The first system involves dual pH/reduction responsive polysaccharide-based bionanogels(ssBNGs) prepared by aqueous crosslinking polymerization. CMC is grafted with pendantoligo(ethylene oxide) containing methacrylate (OEOMA), and crosslinked with a disulfidelabeled dimethacrylate, yielding disulfide crosslinked ssBNGs with a diameter ≈ 24 nmmeasured by dynamic light scattering. ssBNGs exhibit dual pH/reduction-responsive drug release, attributed to less interactions between the encapsulated drug molecules and CMC at acidic pH and the reductive cleavage of disulfide crosslinkers. The possibility of conjugating atargeting ligand to ssBNGs is confirmed with a model water-soluble UV-active dye.The second system includes dual pH/temperature responsive bionanogels (DuR-BNGs). Thermoresponsive polymers undergo volume change above their lower critical solution temperature (LCST) due to a hydrophilic/hydrophobic transition. DuR-BNGs were prepared by grafting thermoresponsive monomers: di(ethylene oxide) methyl ether methacrylate (MEO2MA) and OEOMA from CMC in the presence of crosslinker via aqueous crosslinking polymerization. The self-association of grafted P(MEO2MA-co-OEOMA) above their LCST resulted in a micelle-like structure of DuR-BNGs as well as narrow size distribution. DuR-BNGs exhibit pH responsive drug release due to the pH-dependent interaction of CMC with drug molecules. Thetemperature-responsive drug release was driven by the shrinkage of DuR-BNGs networks upon high temperature treatment, thereby expelling encapsulated cargoes causing rapid drug release. The non-specific protein absorption of DuR-BNGs is evaluated with bovine serum albumin(BSA) as a model. The potential application of two types of dual stimuli-responsive bionanogels (BNGs) in drug delivery is demonstrated with cell viability by MTT assay and cellular uptake using confocal laser scanning microscopy and flow cytometry." @default.
- W926886952 created "2016-06-24" @default.
- W926886952 creator A5073149552 @default.
- W926886952 date "2015-03-01" @default.
- W926886952 modified "2023-09-27" @default.
- W926886952 title "Synthesis of carboxymethyl cellulose (CMC)-based bionanogels for dual stimuli-responsive drug release and cancer therapy" @default.
- W926886952 hasPublicationYear "2015" @default.
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