FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W927513319> ?p ?o ?g. }

• W927513319 abstract "Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine including tissue engineering, dermatological fillers, and viscosupplementation for osteoarthritis treatment. The cytotoxicity of crosslinking techniques for scaffold fabrication and the high viscosity of viscosupplements have been issues impeding the development of products from HA. Thus, novel HA biomaterials for tissue engineering and improved properties of viscosupplements are in demand. Nanotechnology can be a useful tool to address these needs. The aim of this dissertation was to synthesize HA nanoparticles and use the fabricated nanoparticles to develop colloidal systems for these proposed biomedical applications. First, nanoparticles were successfully synthesized using a technique free of an oil and surfactant. Nanoparticles then were employed to develop colloidal gels and suspensions. Several methods were used to characterize nanoparticles, colloidal gels, and colloidal suspensions including dynamic light scattering, uniaxial compression testing, and rheometry. Factors such as polymer type, concentration of polymer, and molecular weight of polymer (17, 741, and 1500 kDa) influenced nanoparticle properties. In addition, mixing nanoparticles composed of 17 kDa HA in deionized water at different concentrations (15%, 30%, and 45% w/v) formed a stable 3-D colloidal gel as a result of physical entanglement of free polymer chains on the surfaces of nanoparticles. Mechanical and rheological investigation showed that Young's modulus, shear modulus, viscosity, and viscoelasticity of colloidal gels are concentration dependent. These investigations also indicated that the colloidal gels had recoverable and dynamic properties. Viscous suspensions were also formed via addition of nanoparticles (17kDa or 1500 kDa) to either deionized water or to hyaluronic acid solution (1500 kDa). Rheological investigations showed that the viscosity and the viscoelasticity of the suspensions can be controlled via interactions between polymer in solution and free polymer chains on the surfaces of nanoparticles. These interactions were shown to be influenced by type of the nanoparticles (17 kDa or 1500 kDa). Overall, a variety of HA nanoparticle formulations were discovered that enable new strategies in tissue scaffolding, dermatological filling, and viscosupplementation." @default.
• W927513319 created "2016-06-24" @default.
• W927513319 creator A5012523500 @default.
• W927513319 date "2012-05-31" @default.
• W927513319 modified "2023-09-27" @default.
• W927513319 title "Biomedical Application of Hyaluronic Acid Nanoparticles" @default.
• W927513319 cites W1787054447 @default.
• W927513319 cites W1969136202 @default.
• W927513319 cites W2001803583 @default.
• W927513319 cites W2009448122 @default.
• W927513319 cites W2026558129 @default.
• W927513319 cites W2048970449 @default.
• W927513319 cites W2068456228 @default.
• W927513319 cites W2069794924 @default.
• W927513319 cites W2071375205 @default.
• W927513319 cites W2071708686 @default.
• W927513319 cites W2075668097 @default.
• W927513319 cites W2083173736 @default.
• W927513319 cites W2092665065 @default.
• W927513319 cites W2116559143 @default.
• W927513319 cites W2150342548 @default.
• W927513319 cites W2163565101 @default.
• W927513319 cites W42533884 @default.
• W927513319 cites W566299537 @default.
• W927513319 cites W2061620000 @default.
• W927513319 hasPublicationYear "2012" @default.
• W927513319 type Work @default.
• W927513319 sameAs 927513319 @default.
• W927513319 citedByCount "2" @default.
• W927513319 countsByYear W9275133192014 @default.
• W927513319 countsByYear W9275133192020 @default.
• W927513319 crossrefType "dissertation" @default.
• W927513319 hasAuthorship W927513319A5012523500 @default.
• W927513319 hasConcept C127172972 @default.
• W927513319 hasConcept C127413603 @default.
• W927513319 hasConcept C142724271 @default.
• W927513319 hasConcept C14631669 @default.
• W927513319 hasConcept C155672457 @default.
• W927513319 hasConcept C159985019 @default.
• W927513319 hasConcept C171250308 @default.
• W927513319 hasConcept C186541917 @default.
• W927513319 hasConcept C191172559 @default.
• W927513319 hasConcept C192562407 @default.
• W927513319 hasConcept C200990466 @default.
• W927513319 hasConcept C204787440 @default.
• W927513319 hasConcept C2776164576 @default.
• W927513319 hasConcept C2777529286 @default.
• W927513319 hasConcept C2909830753 @default.
• W927513319 hasConcept C3019843197 @default.
• W927513319 hasConcept C42360764 @default.
• W927513319 hasConcept C521977710 @default.
• W927513319 hasConcept C54355233 @default.
• W927513319 hasConcept C59789625 @default.
• W927513319 hasConcept C71924100 @default.
• W927513319 hasConcept C86803240 @default.
• W927513319 hasConceptScore W927513319C127172972 @default.
• W927513319 hasConceptScore W927513319C127413603 @default.
• W927513319 hasConceptScore W927513319C142724271 @default.
• W927513319 hasConceptScore W927513319C14631669 @default.
• W927513319 hasConceptScore W927513319C155672457 @default.
• W927513319 hasConceptScore W927513319C159985019 @default.
• W927513319 hasConceptScore W927513319C171250308 @default.
• W927513319 hasConceptScore W927513319C186541917 @default.
• W927513319 hasConceptScore W927513319C191172559 @default.
• W927513319 hasConceptScore W927513319C192562407 @default.
• W927513319 hasConceptScore W927513319C200990466 @default.
• W927513319 hasConceptScore W927513319C204787440 @default.
• W927513319 hasConceptScore W927513319C2776164576 @default.
• W927513319 hasConceptScore W927513319C2777529286 @default.
• W927513319 hasConceptScore W927513319C2909830753 @default.
• W927513319 hasConceptScore W927513319C3019843197 @default.
• W927513319 hasConceptScore W927513319C42360764 @default.
• W927513319 hasConceptScore W927513319C521977710 @default.
• W927513319 hasConceptScore W927513319C54355233 @default.
• W927513319 hasConceptScore W927513319C59789625 @default.
• W927513319 hasConceptScore W927513319C71924100 @default.
• W927513319 hasConceptScore W927513319C86803240 @default.
• W927513319 hasLocation W9275133191 @default.
• W927513319 hasOpenAccess W927513319 @default.
• W927513319 hasPrimaryLocation W9275133191 @default.
• W927513319 hasRelatedWork W1555402354 @default.
• W927513319 hasRelatedWork W1846706585 @default.
• W927513319 hasRelatedWork W1996800900 @default.
• W927513319 hasRelatedWork W2057837944 @default.
• W927513319 hasRelatedWork W2066811064 @default.
• W927513319 hasRelatedWork W2072060857 @default.
• W927513319 hasRelatedWork W2092887231 @default.
• W927513319 hasRelatedWork W2134715649 @default.
• W927513319 hasRelatedWork W2155881078 @default.
• W927513319 hasRelatedWork W2160698351 @default.
• W927513319 hasRelatedWork W2314987682 @default.
• W927513319 hasRelatedWork W2607973499 @default.
• W927513319 hasRelatedWork W2747288337 @default.
• W927513319 hasRelatedWork W2794098203 @default.
• W927513319 hasRelatedWork W2804477276 @default.
• W927513319 hasRelatedWork W2946313059 @default.
• W927513319 hasRelatedWork W2965220123 @default.
• W927513319 hasRelatedWork W3047384346 @default.
• W927513319 hasRelatedWork W3110122116 @default.
• W927513319 hasRelatedWork W2832631392 @default.

• next