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- W92768914 abstract "The effect of x radiation on the ascorbic acid content of the spleen was studied as a function of the dose rate. Wistar rats with a weight of about 250 g were exposed io whole-body irradiation of single doses oi 200 and 400 r and to daily fractional doses of 2O or 50 r. The rats exposed to single 200 r exposures exhibited a very rapid deccrease in the ascorbic acid content of the spleen for about 48 hr. The reduction was approximately 60%. An increase in the ascorbic acid then occurred and reached its maximum in 96 hr. A second decrease which is smaller than the first and attains 40% in 150 hr, is then observed. With a single dose of 400 r the decrease inascorbic acid is extremely rapid even two hours after irradiation. The decrease continues without interruption except for a slight arrest at 50 hr. The animals exposed to fractional doses were sacrificed 24 hr after the last irradiation. For frictional doses of 50 r a definite decrease in ascorbic acid is noticed after only one exposure. The decrease continues progressively as a function of the total dose and is 50% for 400 r. For fractionalmore » doses of 20 r, no decrease in ascorbic acid is found until the total exposure is 250 r. and for 500 to 600 r the decrease is of the order of 10 to 15%. (J.S.R.)« less" @default.
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- W92768914 date "1959-11-24" @default.
- W92768914 modified "2023-09-23" @default.
- W92768914 title "EFFECT OF X RADIATION ON THE ASCORBIC ACID CONTENT OF SPLEEN TISSUE" @default.
- W92768914 hasPublicationYear "1959" @default.
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