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- W92770187 abstract "The human P blood group system was discovered by Landsteiner and Levine (1927) when these investigators found a new antigen present on the erythrocytes of about 80% of individuals, who were typed P(+), and absent on others, who were typed P(−). The system was defined by one antibody, anti-P, and one antigen, P. Then, Levine et al. (1951,1954) discovered a new antibody recognizing an antigen, termed Tja, present on erythrocytes of everyone but very rare individuals. By 1955, 15 people in the world, members of 9 families, were known to lack Tja on their red blood cells and contain anti-Tja in their serum. Sanger (1955) found that six out of six Tj(a-) individuals were P-negative, a proportion very improbable to occur by chance. Furthermore, anti-Tja sera were able to agglutinate P-negative as well as P-positive red cells, indicating that P-negative cells share a common antigen with P-positive cells. The P blood group system was redefined in order to include these new findings: original common P(+) and P(−) phenotypes became P1 and P2, respectively, and the new rare phenotype, previously called Tja−, was termed “little p.” A new antigen, common to P1 and P2 and lacking in p individuals, was termed P. The anti-Tja antisera were found to contain anti-P1 and anti-P antibodies." @default.
- W92770187 created "2016-06-24" @default.
- W92770187 creator A5015743161 @default.
- W92770187 creator A5041386292 @default.
- W92770187 date "1995-01-01" @default.
- W92770187 modified "2023-10-17" @default.
- W92770187 title "P Blood Group and Related Antigens" @default.
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