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- W927875325 abstract "Anxiety is a widespread disorder in world wide. Some amount of anxiety always associated with depression. In this study we tested anti-anxiety effect of tramadol in Elevated plus Maze apparatus (EPM). Tramadol is a synthetic centrally acting opioid analgesic. It is a weak µ opioid receptor agonist and also act as an anti-depressant by inhibiting uptake of noradrenaline and serotonin. Rats (150-250g) of either sex were randomly divided into 4 groups of 6 animals each. Tramadol was administered at two different doses (20, 40 mg/kg, i.p) 30 mints before conducting test. No of entries and time spent in both closed and open arm observed. The antianxiety effect of tramadol was compared to that of diazepam (2 mg/kg, i.p), in elevated plus maze apparatus (EPM).The result of the study shows that tramadol dose dependently increases entries and time in open arm (40mg/Kg) in EPM. Tramadol showed anti-anxiety activity in Elevated Plus Maze apparatus." @default.
- W927875325 created "2016-06-24" @default.
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- W927875325 date "2015-04-12" @default.
- W927875325 modified "2023-09-26" @default.
- W927875325 title "Effect of tramadol in elevated plus maze apparatus- A rodent model of anxiety." @default.
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