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- W92797299 abstract "Cyclosporine A is a commonly used immunosuppressant in organ transplant. However, in addition to its nephro-and hepatotoxicity, we now report that it also exerts growth inhibiting effects in vivo and in vitro . Rats treated with daily Cyclosporine A I.P. injections of 10 mg or 20 mg/kg body weight gained weight at significantly lower rates than controls over a six week period. This growth retardation was completely reversible. By 6 weeks post treatment, the body weights of the treated animals were the same as controls. In contrast, rats treated with lower doses of cyclosporine A (5 mg/kg) did not suffer any growth retardation throughout. In vitro , rat primary cultured fibroblasts treated with >1 μg / ml Cyclosporine A suffered 25–60% cell loss in the post-log phase but the cytotoxic effect was not apparent during the log phase of growth. Fibroblasts treated with ⩽ 1 μg / ml of Cyclosporine A did not suffer any cell loss. In conclusion, Cyclosporine A exerts growth inhibitory effects in vivo when given at >5 mg / kg body weight and cytotoxic effects in vitro at >1 μg / ml ." @default.
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- W92797299 date "1991-01-01" @default.
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- W92797299 title "Growth inhibition by cyclosporine a and" @default.
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- W92797299 doi "https://doi.org/10.1016/0024-3205(91)90182-b" @default.
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