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- W928136446 abstract "Abstract NLR proteins are a diverse family of pattern recognition receptors that modulate immune system homeostasis in the gastrointestinal system. Recent studies have identified a sub-group of inflammasome forming NLRs that modulate the mucosal immune response during inflammatory bowel disease (IBD) and colitis associated tumorigenesis. To better elucidate the contribution of NLR family members in IBD and cancer, we conducted a retrospective analysis of gene expression metadata from human patients. These data revealed that NLRP1, an inflammasome forming NLR, was significantly dysregulated in IBD and colon cancer. To better characterize the function of NLRP1 in disease pathogenesis, we utilized Nlrp1b-/- mice in experimental colitis and colitis associated cancer models. Nlrp1b-/- mice demonstrated significant increases in inflammation and tumorigenesis compared to wild type mice. The increased inflammation and tumor burden was correlated with attenuated levels of IL-1β and IL-18. Further mechanistic studies revealed the increased disease pathogenesis in the Nlrp1b-/- mice was associated with non-hematopoietic derived cells and suggests that NLRP1 functions in the colon epithelial cells to attenuate tumorigenesis. Together, these data identify NLRP1 as an essential mediator of the host immune response during IBD and cancer. These findings are consistent with a model whereby multiple NLR inflammasomes attenuate disease pathobiology through modulating IL-1β and IL-18 levels in the colon." @default.
- W928136446 created "2016-06-24" @default.
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- W928136446 date "2015-05-01" @default.
- W928136446 modified "2023-09-27" @default.
- W928136446 title "The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis (MUC5P.750)" @default.
- W928136446 doi "https://doi.org/10.4049/jimmunol.194.supp.138.8" @default.
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