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• W92904192 abstract "It is logical to tailor radiation dose schedule according to the therapeutic goals, i.e., curative versus pal-liative to achieve the best possible outcome for a given clinical condition. Not all patients with stage III served optimally by administering the same dose of radiation or chemo-radiotherapy regimen. The aim of this study is to update the recent progress in the clinical research in escalation of radiation dose/dose intensity and radiotherapeutic/predictive factors of radiation response which may be useful in guiding high dose radiation therapy in chemo-radiation (CT+RT) for beter outcome. The current literatures (1985–2001) on clinical research in escalation of radiation dose/dose intensity were reviewed for radiotherapeutic factors, which are important in tumor response and therapy outcome. Also reviewed were translational research in genetic/radiobiological/metabolic markers for the identification of useful biomarkers in predicting therapy response to radiation therapy or CT+RT. Reports on combined therapy for stage III NSCLC were also reviewed for the toxicity, tumor response and survival outcome. Factors important for predicting therapy outcome in NSCLC are grouped as follows: Current data indicate that there is a dose-response relationship between radiation dose and local tumor control, and also between local tumor control and survival in stage III NSCLC. Therafore, the radiotherapeutic factors, i.e., total radiation dose, fractionation schedule and dose intensity, the use of 3-D conformal radiation to secure the optimum therapeutic ratio are important for improved local tumor control and survival. Future research should be directed towards radiation dose escalation using 3-D conformal therapy to determine the maximum tolerated dose (MTD) of radiation in a setting of chemo-radiotherapy, and the use of this MTD for improved local tumor control and survival. Radiobiological, molecular, and metabolic markers may offer a potential for monitoring tumor response and optimizing radiation therapy accordingly." @default.
• W92904192 created "2016-06-24" @default.
• W92904192 creator A5044887899 @default.
• W92904192 creator A5077060495 @default.
• W92904192 date "2002-01-01" @default.
• W92904192 modified "2023-09-27" @default.
• W92904192 title "Recent progress in optimizing radiotherapy in chemo-radiotherapy for stage III non-small cell lung cancer" @default.
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• W92904192 doi "https://doi.org/10.1007/bf02711634" @default.
• W92904192 hasPublicationYear "2002" @default.
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