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- W92911974 abstract "We evaluated the effect of the MTHFR C→T polymorphism on global DNA methylation from a double-blind randomized controlled trial in which Chinese women of reproductive age took supplements of folic acid (100, 400, 4000 μg/d). DNA methylation was expressed as the % of methyl-C/C (measured by a novel LC-MS/MS assay) at 0, 1, 3, 6 months of supplementation, and 3 months after withdraw, stratified by MTHFR genotype (CC, CT, TT) (n=135; 15 subjects/genotype x 3 treatment groups). Baseline methylation levels (4.4 +/− 0.12) were identical (p>0.05) across the MTFHR genotypes. Folic acid supplementation resulted in a 13% (p< 0.0001) decrease in global methylation after 1 month of exposure, independently of genotype and dose. After 6 months of supplementation, DNA methylation had returned to baseline in the CT- and TT-subjects taking 100 or 400 μg/d folic acid, but not in CC-subjects, or in any subject receiving 4 mg/d. During the 3 month washout, DNA methylation decreased further in CC- and CT-, but not in the TT-subjects. This post-supplementation decrease in methylation was both genotype and dose dependent, being greatest (compared to baseline) in CC-subjects taking the 100 μg/d dose (42%, p=0.0001). In conclusion, global DNA methylation response to folic acid supplementation and withdrawal varied by MTHFR genotype with a complex genotype-dose interaction. Support: Collaborative CDC agreement and GCRC Grant # MO1-RR00082." @default.
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- W92911974 date "2008-03-01" @default.
- W92911974 modified "2023-09-26" @default.
- W92911974 title "Changes in global DNA methylation in response to chronic consumption and withdrawal of folic acid is dependent on the MTHFR 677C T polymorphism" @default.
- W92911974 doi "https://doi.org/10.1096/fasebj.22.1_supplement.689.6" @default.
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