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- W929705066 abstract ") kept infreshwater at 20-23. The distribution of the drug was studied after treatment. At points timed, from 1 h to96 hrs after administration, blood (B), liver (L), kidney (K) and muscle (M) from 5 individuals in eachgroup were collected for analyse with microbiological bioassay method. The peak concentrations were mea-sured at 8 h (L), 12 h (B and K) and 24 h (M) after administration regardless of treated drugs. Considerablyhigh concentrations of CPF (13.8-19.6 `L) NRF (11.8-16.9 `L) and OXA (10.8-13.9 `L) wererevealed during the 24 h. At the last time point of the experiment (96 h), concentrations of all threequinolones were: OXA, 2.3-6.3 `L; NRF, 3.1-4.5 `L; CPF, 3.0-5.5 `Lin samples. The concentra-tions decreased subsequently, indicating a first rapid redistribution, followed by a slow phase of elimination.The steady state was observed in blood (12-36 h), liver (12-96 h) and muscle (36-96 h) after the initiation oftreatment with OXA. Concerning the compartmental concentrations, (L, K, and M/B concentration ratio),the fluctuation of the ratio was founded at different time points, among drugs. For CPF, highest tissue ratioswere prolonged in the order of L>K>M (0.65-1.2/0.82-0.93/1.0-1.7) during the experiments. On the otherhand, NRF presented L>K>M (0.65-1.3/0.86-1.0) till 24 h, but L>M>K (0.89-1.26) at 36-96 h. OXAshowed L>K>M (0.95-2.1) at 1-8 h, M>K>L (0.51-1.0) at 12-36 h and M>L>K (1.0-2.3) at 48-96 h, respec-tively." @default.
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- W929705066 date "2005-01-01" @default.
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- W929705066 title "Distribution of Quinolones (Ciprofloxacin, Norfloxacin and Oxolinic acid) after Oral Administration in Carp (Cyprinus carpio)" @default.
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