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- W929805216 abstract "目的：通过检测环孢素A（cyclosporin A,CsA）作用下牙龈组织TGF-β1和PCNA的表达情况,探讨CsA导致牙龈过度生长（gingival overgrowth,GO）可能的病理机制。方法：20只单侧拔除下颌磨牙的SD大鼠随机分为实验组（CsA,10mg.kg^-1·d^-1皮下注射）和对照组（等量生理盐水皮下注射）。4周后处死动物,截取下颌磨牙区组织用以检测。体视显微镜下测量牙龈宽度;标本脱钙后制片,经HE染色,行牙龈组织学镜检测量;免疫组化方法（ABC法）检测标本牙龈TGF-β1、PCNA的表达情况。以Image Pro-plus 6.0图像分析软件,对免疫组化检测结果作半定量分析,并以SAS 6.12软件包进行统计学处理。结果：实验组用药后4周,有牙侧与无牙侧牙龈TGF-β1、PCNA蛋白表达水平升高,与对照组比较具有显著差异;各组内有牙侧与无牙侧牙龈的TGF-β1、PCNA表达水平无显著差异。结论：CsA导致GO的过程中,牙龈TGF-β1表达水平上调及其作用可能独立于牙龈炎症,CsA有刺激牙龈成纤维细胞过量表达TGF-β1的作用;CsA促进牙龈上皮增殖活性的提高,可能是上皮细胞数量增加、上皮层增厚的主要原因。" @default.
- W929805216 created "2016-06-24" @default.
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- W929805216 date "2011-04-10" @default.
- W929805216 modified "2023-09-24" @default.
- W929805216 title "环孢素A作用下牙龈组织TGF-β1、PCNA蛋白的表达" @default.
- W929805216 hasPublicationYear "2011" @default.
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