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- W93011168 abstract "Abstract Asthma is a chronic inflammatory airway disease with a nationwide prevalence of ~6%. It is associated with goblet cell metaplasia and airway hyperreactivity (AHR). Models of allergen-induced asthma exhibit increased levels of stem cell factor (SCF) and the accumulation of myeloid derived SCF receptor (c-kit)+ cells in the airway. Anti-SCF antibody treatments into the airway attenuate Th2 cytokine responses and reduce IL-25 responsiveness in CRA challenged mice in a T cell independent manner. Additional data have identified that an IL-25R+ myeloid cell accumulates in the lung during chronic allergen responses and contributes to Th2 cytokine production. When W/Wv mice were sensitized and challenged with allergen, AHR and mucous hypersecretion responses were significantly attenuated along with overall inflammatory responses. A significant reduction in IL-25R+ myeloid cells was a prominent feature that correlated with reduced Th2 cytokine responses. Subsequent experiments will further define the responses using adoptive transfer of wildtype myeloid progenitor cells to define whether the IL-25R+ myeloid cell population is reconstituted along with Th2 cytokine responses and pathophysiology. This work was supported by NIH grant HL59178" @default.
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- W93011168 date "2009-04-01" @default.
- W93011168 modified "2023-09-25" @default.
- W93011168 title "SCF and IL-25 induced Th2 associated pathophysiology in chronic cockroach antigen induced asthma (79.19)" @default.
- W93011168 doi "https://doi.org/10.4049/jimmunol.182.supp.79.19" @default.
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