FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W930113364> ?p ?o ?g. }

• W930113364 abstract "ObjectiveWe aimed to find out the small molecules affected by PFO closure. The changes of these factors should be closely related to the pathology of PFO-related stroke.BackgroundPFO can increase the risk of stroke by enabling direct mixing of venous and arterial circulation and serving as a conduit for venous clots. Our previous study found that PFO disturbs pulmonary filtration of harmful factor, serotonin (5HT), which stays high in circulation and creates a prothrombotic state. In the context of endovascular PFO closure, a bedside model to understand PFO circulatory signaling, we performed a full metabolomic profile of other mediators that may respond to PFO closure.MethodPatients were recruited in accordance with IRB approval. Plasma was sampled from left (LA) and right (RA) atria pre and post PFO closure and also from venous 3 months post closure. A discovery metabolite screening was performed in 14 patients and analysis was performed with one-way ANOVA.ResultWith strict analysis (537 metabolites, one-way ANOVA, p<0.01), we identified homocysteine (HCY) with the most prominent change after PFO closure. While HCY levels in the left atrium (LA) and right atrium (RA) were comparable pre-closure (pre-LA: 5.61±0.09; pre-RA: 5.30±0.48), HCY immediately decreased in LA post closure (post-LA: 4.56±0.04) and remained low in peripheral venous blood at 3-month follow-up (4.57±0.06; p=0.0036).ConclusionWe found PFO closure to lower HYC immediately in left atrial (arterial) blood, and this effect persists in peripheral venous circulation at 3 months post procedure. Since high level of HYC is independently associated with stroke and heart disease, our results suggest that mechanical PFO repair may improve circulatory profile of PFO stroke patients. Studies in a larger patient cohort and validation of other important metabolites are ongoing. Disclosure: Dr. Deng has nothing to disclose. Dr. Beecher has nothing to disclose. Dr. Burant has nothing to disclose. Dr. Lopez has nothing to disclose. Dr. De Jong has nothing to disclose. Dr. Palacios has nothing to disclose. Dr. Inglessis has nothing to disclose. Dr. Silverman has nothing to disclose. Dr. Feeney has nothing to disclose. Dr. Elia has nothing to disclose. Dr. Wickham has nothing to disclose. Dr. McMullin has nothing to disclose. Dr. Dec has nothing to disclose. Dr. Buonanno has nothing to disclose. Dr. Eng H has nothing to disclose. Dr. Ning has nothing to disclose." @default.
• W930113364 created "2016-06-24" @default.
• W930113364 creator A5000651197 @default.
• W930113364 creator A5002163683 @default.
• W930113364 creator A5018739306 @default.
• W930113364 creator A5020104307 @default.
• W930113364 creator A5024628877 @default.
• W930113364 creator A5034622744 @default.
• W930113364 creator A5042287830 @default.
• W930113364 creator A5044040854 @default.
• W930113364 creator A5047006276 @default.
• W930113364 creator A5049065033 @default.
• W930113364 creator A5049113805 @default.
• W930113364 creator A5054894697 @default.
• W930113364 creator A5074459418 @default.
• W930113364 creator A5077710020 @default.
• W930113364 creator A5087058296 @default.
• W930113364 creator A5091447153 @default.
• W930113364 date "2015-04-06" @default.
• W930113364 modified "2023-09-23" @default.
• W930113364 title "Metabolomic analysis of PFO-related stroke shows immediate and persistent decrease of homocysteine post PFO closure (P2.277)" @default.
• W930113364 hasPublicationYear "2015" @default.
• W930113364 type Work @default.
• W930113364 sameAs 930113364 @default.
• W930113364 citedByCount "0" @default.
• W930113364 crossrefType "journal-article" @default.
• W930113364 hasAuthorship W930113364A5000651197 @default.
• W930113364 hasAuthorship W930113364A5002163683 @default.
• W930113364 hasAuthorship W930113364A5018739306 @default.
• W930113364 hasAuthorship W930113364A5020104307 @default.
• W930113364 hasAuthorship W930113364A5024628877 @default.
• W930113364 hasAuthorship W930113364A5034622744 @default.
• W930113364 hasAuthorship W930113364A5042287830 @default.
• W930113364 hasAuthorship W930113364A5044040854 @default.
• W930113364 hasAuthorship W930113364A5047006276 @default.
• W930113364 hasAuthorship W930113364A5049065033 @default.
• W930113364 hasAuthorship W930113364A5049113805 @default.
• W930113364 hasAuthorship W930113364A5054894697 @default.
• W930113364 hasAuthorship W930113364A5074459418 @default.
• W930113364 hasAuthorship W930113364A5077710020 @default.
• W930113364 hasAuthorship W930113364A5087058296 @default.
• W930113364 hasAuthorship W930113364A5091447153 @default.
• W930113364 hasConcept C126322002 @default.
• W930113364 hasConcept C127413603 @default.
• W930113364 hasConcept C146834321 @default.
• W930113364 hasConcept C151730666 @default.
• W930113364 hasConcept C162324750 @default.
• W930113364 hasConcept C164705383 @default.
• W930113364 hasConcept C2777090595 @default.
• W930113364 hasConcept C2779343474 @default.
• W930113364 hasConcept C2780645631 @default.
• W930113364 hasConcept C34447519 @default.
• W930113364 hasConcept C42219234 @default.
• W930113364 hasConcept C43044207 @default.
• W930113364 hasConcept C46762472 @default.
• W930113364 hasConcept C71924100 @default.
• W930113364 hasConcept C72859922 @default.
• W930113364 hasConcept C78519656 @default.
• W930113364 hasConcept C86803240 @default.
• W930113364 hasConceptScore W930113364C126322002 @default.
• W930113364 hasConceptScore W930113364C127413603 @default.
• W930113364 hasConceptScore W930113364C146834321 @default.
• W930113364 hasConceptScore W930113364C151730666 @default.
• W930113364 hasConceptScore W930113364C162324750 @default.
• W930113364 hasConceptScore W930113364C164705383 @default.
• W930113364 hasConceptScore W930113364C2777090595 @default.
• W930113364 hasConceptScore W930113364C2779343474 @default.
• W930113364 hasConceptScore W930113364C2780645631 @default.
• W930113364 hasConceptScore W930113364C34447519 @default.
• W930113364 hasConceptScore W930113364C42219234 @default.
• W930113364 hasConceptScore W930113364C43044207 @default.
• W930113364 hasConceptScore W930113364C46762472 @default.
• W930113364 hasConceptScore W930113364C71924100 @default.
• W930113364 hasConceptScore W930113364C72859922 @default.
• W930113364 hasConceptScore W930113364C78519656 @default.
• W930113364 hasConceptScore W930113364C86803240 @default.
• W930113364 hasLocation W9301133641 @default.
• W930113364 hasOpenAccess W930113364 @default.
• W930113364 hasPrimaryLocation W9301133641 @default.
• W930113364 hasRelatedWork W124263678 @default.
• W930113364 hasRelatedWork W1494023413 @default.
• W930113364 hasRelatedWork W1560350240 @default.
• W930113364 hasRelatedWork W2038056671 @default.
• W930113364 hasRelatedWork W2117799869 @default.
• W930113364 hasRelatedWork W2154944889 @default.
• W930113364 hasRelatedWork W2188629863 @default.
• W930113364 hasRelatedWork W2314073268 @default.
• W930113364 hasRelatedWork W2334937417 @default.
• W930113364 hasRelatedWork W2388606731 @default.
• W930113364 hasRelatedWork W2407234748 @default.
• W930113364 hasRelatedWork W2418448590 @default.
• W930113364 hasRelatedWork W2418997363 @default.
• W930113364 hasRelatedWork W2559078380 @default.
• W930113364 hasRelatedWork W2571987088 @default.
• W930113364 hasRelatedWork W2750187695 @default.
• W930113364 hasRelatedWork W2770148288 @default.
• W930113364 hasRelatedWork W2790529755 @default.
• W930113364 hasRelatedWork W3016168947 @default.
• W930113364 hasRelatedWork W3135614696 @default.
• W930113364 hasVolume "84" @default.

• next