Matches in SemOpenAlex for { <https://semopenalex.org/work/W93017588> ?p ?o ?g. }
- W93017588 abstract "While the prevalence of maternal While the prevalence of diabetes mellitus reaches epidemic proportions, most available treatments still focus on the symptoms of the disease, rather than the underlying pathology. Types 1 and 2 diabetes have in common a deficit in β-cell mass. In type 1 diabetes, auto-immune β-cell destruction leads to an absolute deficit in β-cells, while in type 2 diabetes, insulin resistance and β-cell dysfunction cause a functional deficit. More recently, however, it has been suggested that type 2 diabetes is also marked by an absolute deficit in β-cell mass, although a causal relationship has not yet been established. Overall β-cell mass reflects the balance between the dynamic processes of β-cell expansion, through proliferation and neogenesis, and β-cell loss via apoptosis. Given that β-cell mass can be modified significantly by altering the rate of any of these mechanisms, therapies that modulate β-cell expansion and loss have garnered recent interest. We review herein the current therapeutics under investigation as modulators of β-cell mass dynamics, and the basic research that supports these novel therapeutic targets." @default.
- W93017588 created "2016-06-24" @default.
- W93017588 creator A5009543517 @default.
- W93017588 date "2020-08-12" @default.
- W93017588 modified "2023-09-25" @default.
- W93017588 title "Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes" @default.
- W93017588 cites W1506652147 @default.
- W93017588 cites W1531601693 @default.
- W93017588 cites W15434046 @default.
- W93017588 cites W1557734333 @default.
- W93017588 cites W1558252822 @default.
- W93017588 cites W1594153431 @default.
- W93017588 cites W1752683265 @default.
- W93017588 cites W1909310469 @default.
- W93017588 cites W1958779837 @default.
- W93017588 cites W1969758937 @default.
- W93017588 cites W1970082668 @default.
- W93017588 cites W1971701221 @default.
- W93017588 cites W1971713572 @default.
- W93017588 cites W1974963144 @default.
- W93017588 cites W1975799894 @default.
- W93017588 cites W1977445442 @default.
- W93017588 cites W1978953702 @default.
- W93017588 cites W1981385494 @default.
- W93017588 cites W1982429274 @default.
- W93017588 cites W1982781304 @default.
- W93017588 cites W1983101319 @default.
- W93017588 cites W1985051436 @default.
- W93017588 cites W1986323183 @default.
- W93017588 cites W1994509817 @default.
- W93017588 cites W1998448364 @default.
- W93017588 cites W1999730970 @default.
- W93017588 cites W2001295992 @default.
- W93017588 cites W2004014076 @default.
- W93017588 cites W2005754586 @default.
- W93017588 cites W2006084494 @default.
- W93017588 cites W2007386368 @default.
- W93017588 cites W2009793859 @default.
- W93017588 cites W2011902888 @default.
- W93017588 cites W2017530920 @default.
- W93017588 cites W2019349250 @default.
- W93017588 cites W2020496264 @default.
- W93017588 cites W2024992738 @default.
- W93017588 cites W2025143098 @default.
- W93017588 cites W2025784989 @default.
- W93017588 cites W2026348270 @default.
- W93017588 cites W2027363052 @default.
- W93017588 cites W2036085625 @default.
- W93017588 cites W2039486174 @default.
- W93017588 cites W2041524851 @default.
- W93017588 cites W2042362312 @default.
- W93017588 cites W2046766433 @default.
- W93017588 cites W2048349743 @default.
- W93017588 cites W2055257326 @default.
- W93017588 cites W2055791664 @default.
- W93017588 cites W2056906860 @default.
- W93017588 cites W2059486127 @default.
- W93017588 cites W2060324707 @default.
- W93017588 cites W2061293427 @default.
- W93017588 cites W2061560651 @default.
- W93017588 cites W2063333452 @default.
- W93017588 cites W2063693981 @default.
- W93017588 cites W2064400437 @default.
- W93017588 cites W2065331665 @default.
- W93017588 cites W2067389522 @default.
- W93017588 cites W2068094755 @default.
- W93017588 cites W2075187450 @default.
- W93017588 cites W2076122324 @default.
- W93017588 cites W2084644091 @default.
- W93017588 cites W2085457180 @default.
- W93017588 cites W2085721222 @default.
- W93017588 cites W2085870340 @default.
- W93017588 cites W2087831937 @default.
- W93017588 cites W2091952693 @default.
- W93017588 cites W2094306282 @default.
- W93017588 cites W2095652239 @default.
- W93017588 cites W2096444181 @default.
- W93017588 cites W2100614900 @default.
- W93017588 cites W2101766292 @default.
- W93017588 cites W2103914657 @default.
- W93017588 cites W2103961634 @default.
- W93017588 cites W2105407346 @default.
- W93017588 cites W2106098502 @default.
- W93017588 cites W2106709311 @default.
- W93017588 cites W2109639904 @default.
- W93017588 cites W2111457140 @default.
- W93017588 cites W2112331088 @default.
- W93017588 cites W2112402615 @default.
- W93017588 cites W2113544353 @default.
- W93017588 cites W2114706736 @default.
- W93017588 cites W2116505197 @default.
- W93017588 cites W2120382531 @default.
- W93017588 cites W2120395764 @default.
- W93017588 cites W2120467396 @default.
- W93017588 cites W2121241877 @default.
- W93017588 cites W2126295203 @default.
- W93017588 cites W2126700142 @default.
- W93017588 cites W2127409471 @default.
- W93017588 cites W2127791191 @default.
- W93017588 cites W2130821995 @default.