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- W930320699 abstract "目的:研究PTEN、ER、PR在原发性乳腺癌组织中的表达及意义.方法:应用免疫组织化学S-P法,检测了5例正常乳腺组织、14例乳腺增生病(不伴非典型增生)组织和40例乳腺癌中PTEN蛋白的表达;EnVision法检测乳腺癌组织中ER、PR的表达.结果:5例正常乳腺组织、14例乳腺增生病组织中均有PTEN蛋白的表达.40例乳腺癌组织中,PTEN蛋白阳性表达率70%(28/40),表达强度与乳腺癌分化程度有关(P＜0.001).分化越差,PTEN蛋白表达越弱.此外,PTEN蛋白阴性表达的乳腺癌,25%(3/12)为ER/PR阳性;而PTEN蛋白表达较强的乳腺癌中,60.7%为ER/PR阳性.两者差异有显著性(P＜0.05).结论:乳腺癌组织中有抑癌基因PTEN的表达缺失,其异常表达可能与乳腺癌的发生、发展及预后有关." @default.
- W930320699 created "2016-06-24" @default.
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- W930320699 date "2003-01-01" @default.
- W930320699 modified "2023-09-23" @default.
- W930320699 title "原发性乳腺癌中PTEN、ER、PR的检测及临床意义" @default.
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