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- W93044914 abstract "Gonadoblastomas are composed of nests of neoplastic germ cells and sex cord derivatives surrounded by ovarian-type stroma. These tumors are found almost exclusively in persons with gonadal dysgenesis associated with a Y chromosome or Y chromosome fragment, and accordingly, the Y chromosome has been implicated in gonadoblastoma oncogenesis. To evaluate this association, we used two-color fluorescence in situ hybridization with chromosome-specific probes to determine the distribution of the X and Y chromosomes in the tumor nests and surrounding stromal cells in paraffin tissue sections of three gonadoblastomas in two patients with gonadal dysgenesis and 45,X/46,XY mosaicism. Statistical analysis of the data from the fluorescence in situ hybridization demonstrated that in all three gonadoblastomas, the proportion of nuclei with a Y chromosome signal was significantly higher in the tumor cells than in the nontumoral cells of the surrounding stroma (P<.001). These results suggest that Y chromosome material participates in gonadoblastoma tumorigenesis." @default.
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- W93044914 date "1997-08-01" @default.
- W93044914 modified "2023-10-16" @default.
- W93044914 title "Gonadoblastomas in 45,X/46,XY Mosaicism:<i>Analysis of Y Chromosome Distribution by Fluorescence In Situ Hybridization</i>" @default.
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- W93044914 doi "https://doi.org/10.1093/ajcp/108.2.197" @default.
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