FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W93060230> ?p ?o ?g. }

• W93060230 endingPage "6" @default.
• W93060230 startingPage "423" @default.
• W93060230 abstract "SINCE January 1965 New York State public health law has required that all newborn infants be tested for phenylketonuria in accordance with regulations of the State commissioner of health. These regulations prescribe the Guthrie inhibition assay procedure (1) as the only test currently fulfilling the legal requirement. In New York State 99.2 percent of all live births occur in hospitals, and the statute and implementing regulations are hospital oriented. However, there is specific provision for testing an infant born outside a hospital and not subsequently admitted to one. Infants must be tested early enough in life so that those with elevated blood phenylalanine levels can be investigated as rapiidly as possible, but because the available tests require ani adequate level of protein intake by the subject, they must be tested late enough to yield valid results. Infants are captive only for their immediate postnatal hospitalization, ordinarily 3-4 days. The relative rarity of hyperphenylalanemia poses an additional problem because a laboratory may not find a positive result in less than 1,000 determinations. In a nationwide survey, only a few laboratories detected all of 75 true positive specimens submitted for evaluation by the Guthrie inhibition assay procedure. A subsequent evaluation revealed that only 16 of 36 laboratories were able to correctly detect all 25 positives in 100 specimens. This work pointed up the desirability of centralizing the laboratory phase of the program. Accordingly, the laboratory of the New York City health department; the division of laboratories and research of the State department of health, Albany; the laboratory of the Onondaga County health department, Syracuse; and the Erie County Laboratory, Buffalo, were designated to make the required tesits. Each of these laboratories processes from 2,000 to 10,000 specimens every month. Thus a presumptive positive, defined in our program as a specimen with 4 mg. per 100 ml. or greater, occurs often enough to keep the technical personnel acquainted with the appearance of such a test result. In the 18 months preceding enactment of the law, more than 400,000 infants were screened for PKU using the Guthrie inhibition assay proicedure in Newv York State and elsewhere (2). In addition to the blood test taken on the day of the infant's discharge from the hospital, each mother was asked to submit a piece of special filter paper saturated in the urine of the infant when he was 3 weeks old and mail it to the laboratory that analyzed the blood specimen. About 300,000 such urine specimens were examined. No case of PKU which had not been identified by the blood test was identified by the examination of the urine specimen. We did not the,refore consider it necessary to require routine blood or urine tests in addition to the test of the specimen taken at discharge. When the regulation was adopted, there were a number of additional methods for mass screening. The Guthrie method, however, was judged most suitable because specimens were readily and inexpensively transmitted to the Dr. Katz is director, bureau of maternal and child health, and Dr. Harro is assistant commissioner, division of preventive services, New York State Department of Health, Albany." @default.
• W93060230 created "2016-06-24" @default.
• W93060230 creator A5032640513 @default.
• W93060230 creator A5046181939 @default.
• W93060230 date "1968-05-01" @default.
• W93060230 modified "2023-09-23" @default.
• W93060230 title "Screening for PKU in New York State." @default.
• W93060230 cites W1700762969 @default.
• W93060230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1891064" @default.
• W93060230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4967446" @default.
• W93060230 hasPublicationYear "1968" @default.
• W93060230 type Work @default.
• W93060230 sameAs 93060230 @default.
• W93060230 citedByCount "1" @default.
• W93060230 crossrefType "journal-article" @default.
• W93060230 hasAuthorship W93060230A5032640513 @default.
• W93060230 hasAuthorship W93060230A5046181939 @default.
• W93060230 hasConcept C119857082 @default.
• W93060230 hasConcept C138816342 @default.
• W93060230 hasConcept C151730666 @default.
• W93060230 hasConcept C159110408 @default.
• W93060230 hasConcept C17319257 @default.
• W93060230 hasConcept C17744445 @default.
• W93060230 hasConcept C187212893 @default.
• W93060230 hasConcept C199539241 @default.
• W93060230 hasConcept C2776169613 @default.
• W93060230 hasConcept C2777267654 @default.
• W93060230 hasConcept C2780016893 @default.
• W93060230 hasConcept C41008148 @default.
• W93060230 hasConcept C512399662 @default.
• W93060230 hasConcept C64869954 @default.
• W93060230 hasConcept C71924100 @default.
• W93060230 hasConcept C74909509 @default.
• W93060230 hasConcept C86803240 @default.
• W93060230 hasConceptScore W93060230C119857082 @default.
• W93060230 hasConceptScore W93060230C138816342 @default.
• W93060230 hasConceptScore W93060230C151730666 @default.
• W93060230 hasConceptScore W93060230C159110408 @default.
• W93060230 hasConceptScore W93060230C17319257 @default.
• W93060230 hasConceptScore W93060230C17744445 @default.
• W93060230 hasConceptScore W93060230C187212893 @default.
• W93060230 hasConceptScore W93060230C199539241 @default.
• W93060230 hasConceptScore W93060230C2776169613 @default.
• W93060230 hasConceptScore W93060230C2777267654 @default.
• W93060230 hasConceptScore W93060230C2780016893 @default.
• W93060230 hasConceptScore W93060230C41008148 @default.
• W93060230 hasConceptScore W93060230C512399662 @default.
• W93060230 hasConceptScore W93060230C64869954 @default.
• W93060230 hasConceptScore W93060230C71924100 @default.
• W93060230 hasConceptScore W93060230C74909509 @default.
• W93060230 hasConceptScore W93060230C86803240 @default.
• W93060230 hasIssue "5" @default.
• W93060230 hasLocation W930602301 @default.
• W93060230 hasOpenAccess W93060230 @default.
• W93060230 hasPrimaryLocation W930602301 @default.
• W93060230 hasRelatedWork W1799730279 @default.
• W93060230 hasRelatedWork W1983879800 @default.
• W93060230 hasRelatedWork W2002589396 @default.
• W93060230 hasRelatedWork W2062806718 @default.
• W93060230 hasRelatedWork W2323599349 @default.
• W93060230 hasRelatedWork W2329922527 @default.
• W93060230 hasRelatedWork W2409500331 @default.
• W93060230 hasRelatedWork W2765584955 @default.
• W93060230 hasRelatedWork W66987675 @default.
• W93060230 hasRelatedWork W973847176 @default.
• W93060230 hasVolume "83" @default.
• W93060230 isParatext "false" @default.
• W93060230 isRetracted "false" @default.
• W93060230 magId "93060230" @default.
• W93060230 workType "article" @default.