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• W930849548 abstract "The Predictive Low Glucose Management (PLGM) system consists of a Medtronic Veo pump, Enlite sensor, MiniLink REAL-Time transmitter, Bluetooth-RF translator and a predictive algorithm operating from a Blackberry smartphone. The system suspended insulin delivery when the pre-set hypoglycaemic threshold of 4.4mmol/L was predicted to be reached in 30 minutes.The aim of this study was to determine the plasma glucose profile with the PLGM system when hypoglycaemia was induced by (a) moderate-intensity exercise, (b) subcutaneous insulin bolus and (c) increasing the overnight basal infusion rate in individuals with type 1 diabetes. The primary outcome was the plasma glucose nadir following each hypoglycaemic stimulus with and without PLGM.Participants performed 30-60 minutes of moderate-intensity exercise or were administered a subcutaneous insulin bolus following a glucose stabilisation period on basal continuous subcutaneous insulin infusion. In participants studied with increased overnight basal rates, hypoglycaemia was induced by increasing basal rates by 180%. They were randomised and studied on 2 separate days; with PLGM off and with PLGM on. On both days, participants were observed until plasma glucose dropped to 2.8mmol/L or were symptomatic." @default.
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• W930849548 date "2015-04-28" @default.
• W930849548 modified "2023-09-27" @default.
• W930849548 title "Performance of a predictive algorithm in sensor-augmented pump therapy in the prevention of hypoglycaemia" @default.
• W930849548 doi "https://doi.org/10.1186/1687-9856-2015-s1-o36" @default.
• W930849548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4428873" @default.
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