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- W93094269 abstract "In the following study the function of gastric mucosa after withdrawal of 4-week suppression of acid secretion was examined. Rats were treated orally for 4 weeks with omeprazole (CAS 73590-58-6, 150 mg/kg/day). While elevated plasma gastrin levels during the treatment returned to normal 4 days after the last dosing, exogenously applied pentagastrin induced higher acid secretion compared with the vehicle-treated controls. Acetylsalicylic acid induced mucosal lesion 3.6-fold over the control as well. In contrast, the HCl-induced lesion was inhibited by 24.4%. These results indicate that not only the acid secretion but also the mucosal protection is enhanced after 4-week treatment with omeprazole in rats." @default.
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- W93094269 date "1998-01-01" @default.
- W93094269 modified "2023-09-23" @default.
- W93094269 title "Gastric mucosal function following withdrawal of omeprazole in rats." @default.
- W93094269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9522036" @default.
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