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- W9313417 abstract "The mortality associated with gram-negative bacteremia remains in the range of 20–35% [1, 2]. In patients developing gram-negative septic shock (i.e. 20–30% of the patients with gram-negative bacteremia and an unknown percentage of the patients with focal gram-negative infections not associated with detectable bacteremia), fatality ratios may reach 50% or more [3–5]. This finding is attributed to the deleterious effects of the lipopolysaccharide (LPS, also called endotoxin), a component of the outer membrane of gram-negative bacteria. Indeed, antibiotics are unable to prevent the toxic effects of LPS, and may even promote the release of LPS from bacteria. A state of shock may also occur during gram-positive bacterial infections, and unfrequently, during fungal and even viral infections. However, both the incidence of shock complicating infections as well as the mortality observed when shock has developed are higher in gram-negative infections than in gram-positive infections." @default.
- W9313417 created "2016-06-24" @default.
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- W9313417 date "1990-01-01" @default.
- W9313417 modified "2023-09-27" @default.
- W9313417 title "Immunotherapy of Gram-negative Septic Shock" @default.
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- W9313417 doi "https://doi.org/10.1007/978-3-642-84125-5_11" @default.
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