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- W931937802 abstract "目的探讨风湿性二尖瓣病变伴心房颤动患者右心房心肌细胞中钙离子依赖性的中性蛋白酶-Ⅰ（Calpain—Ⅰ）水平、超微结构及其变化关系。方法30例风湿性二尖瓣病变行二尖瓣置换手术的患者，窦性心律及房颇者各15例。分别为对照组及观察组。应用免疫印迹法（Western blot）测定两组心肌细胞内Calpain-Ⅰ水平Ⅰ透射电镜观察心房肌细胞超微结构改变，并分析比较二者之间的关系。结果观察组Calpain-Ⅰ含量（1．585±0．260）明显高于对照组（1．191±0．099），P〈0．01；心房肌细胞肌纤维溶解、线粒体增生、糖元累积明显上升，肌小节溶解指数（SST，31．40％±6．48％）亦明显高于对照组（12．13％±3．16％），P〈0．01；Calpain—Ⅰ水平与SST呈明显正相关（r=0．844，P〈0．01）。结论风湿性二尖瓣病变伴慢性房颤患者的心肌细胞Calpain-Ⅰ水平明显升高，且与超微结构重构关系密切Calpain—Ⅰ参与与慢性房颤心房肌细胞超微结构重构。" @default.
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- W931937802 date "2007-01-01" @default.
- W931937802 modified "2023-09-23" @default.
- W931937802 title "慢性心房颤动患者心肌细胞中Calpain-I水平、超微结构变化及其相关性探讨" @default.
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