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- W93202339 endingPage "1073" @default.
- W93202339 startingPage "1051" @default.
- W93202339 abstract "Ascorbic acid (vitamin C) occurs physiologically as the ascorbate anion. Ascorbate is a water-soluble antioxidant found throughout the body, but occurs in especially high concentrations (10 mM) in neurons. In the central nervous system (CNS), ascorbate is part of the antioxidant network, and as such is normally neuroprotective. Recent studies suggest that ascorbate may play a unique role in the CNS by permitting signaling by a novel diffusible messenger, hydrogen peroxide (H2O2), yet providing protection from damage from the reactive hydroxyl radical, which can be formed from H2O2 oxidation. In order to learn about the function of ascorbate in the CNS, it is necessary to understand how it is compartmentalized. Ascorbate enters the CNS primarily by active transport at the choroid plexus, but also by uptake of oxidized ascorbate, dehydroascorbate, via glucose transporters. After entry into the cerebrospinal fluid (CSF), it diffuses into brain extracellular fluid (ECF), where its concentration is regulated homeostatically, as well as dynamically. From ECF, ascorbate is taken up into brain cells, where it is further concentrated up to 20-fold. Thus, brain ascorbate is located predominantly in the intracellular compartment of brain tissue, with complementary distribution between neurons and glia that may contribute importantly to its role as a neuroprotective agent that also permits redox signaling." @default.
- W93202339 created "2016-06-24" @default.
- W93202339 creator A5043025373 @default.
- W93202339 date "2011-12-17" @default.
- W93202339 modified "2023-10-02" @default.
- W93202339 title "Brain Ascorbate: Protective, Yet Permissive for Redox Signaling" @default.
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