FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W932024246> ?p ?o ?g. }

• W932024246 abstract "Phthalate esters (PEs) are a group of orbat& chemicals used mainly as plasticizers. Due to their widespread use and their ability to leach from various products, PEs are considered ubiquitous environmental contaminants. Phthalate di-esters (DPEs) and their mono-ester metabolites (MPEs) have been linked to a variety of toxic effects, including endocrine disruption. Despite a wide range of Kows, previous work has shown that DPEs do not biomagnify in marine food webs. Biotransformation is believed to limit DPE bioaccumulation, but the specific role of metabolism in limiting DPE accumulation via the diet is not well understood. This study examines the dietary uptake and biotransformation of phthalate esters in Staghorn sculpin (Leptocottus armatus). Sculpin were fed a diet containing DPEs and PCBs, and PCBs, DPEs and MPE metabolites were measured in the food, stomach, intestine, liver and muscle tissue over time. Results show that phthalate di-esters are extensively metabolized to phthalate mono--&--:&L--. IL~r + r . m m n k -A un+ne+anee i i i r i ~ teinn nrsrii~nic h m i h t a a n ihp I i nrlri t . 3 L G I 3 11 1 11 I= 3bUlplll J L u 1 1 law 1 UI IU 11 l r r y r a s mvv. u m m m u u # v n I y m . ~ . ~ . .-. -.-... --. . . . , 3--internal tissues indicate the potential for both DPE and MPE dietary uptake. Significant increases of DMP, BBP, DnOP and MEHP above background levels were measured in sculpin tissues over time, but steady state concentrations remained low. Significant dietary uptake was not detected for all other DPE and MPE congeners. DPEs did not biomagnify. Gut metabolism appears to reduce the dietary uptake of phthalate di-esters and is believed to explain the lack of DPE biomagnification observed in marine food webs. However, un-metabolized DPEs and the MPEs produced by gut metabolism may still be absorbed across the gut wall. DPE and MPE absorption may be balanced by rapid elimination to produce the low steady state levels observed in the tissues. The gross flux of DPEs and MPEs across the gut wall may therefore be relatively high. Four mid-Kow MPEs (MBP, MBzP, MEHP and MOP) were detected in fish tissues (liver and muscle). For these congeners, MPEs & DPEs were found at relatively equal concentrations in sculpin muscle. Similar patterns may exist in wild fish. iii" @default.
• W932024246 created "2016-06-24" @default.
• W932024246 creator A5022871139 @default.
• W932024246 date "2003-01-01" @default.
• W932024246 modified "2023-09-27" @default.
• W932024246 title "Dietary uptake and biotransformation of Phthalate esters in Staghorn sculpin" @default.
• W932024246 cites W1530215206 @default.
• W932024246 cites W1592112313 @default.
• W932024246 cites W1971106809 @default.
• W932024246 cites W1979424845 @default.
• W932024246 cites W1982835302 @default.
• W932024246 cites W1988264129 @default.
• W932024246 cites W1991042434 @default.
• W932024246 cites W1992383300 @default.
• W932024246 cites W1992390233 @default.
• W932024246 cites W1993207015 @default.
• W932024246 cites W1996304921 @default.
• W932024246 cites W1998056446 @default.
• W932024246 cites W1999994029 @default.
• W932024246 cites W2000160637 @default.
• W932024246 cites W2009030826 @default.
• W932024246 cites W2009531665 @default.
• W932024246 cites W2009688144 @default.
• W932024246 cites W2009750043 @default.
• W932024246 cites W2014780973 @default.
• W932024246 cites W2018080649 @default.
• W932024246 cites W2040393890 @default.
• W932024246 cites W2044505224 @default.
• W932024246 cites W2044981779 @default.
• W932024246 cites W2052874387 @default.
• W932024246 cites W2059785305 @default.
• W932024246 cites W2063580467 @default.
• W932024246 cites W2064140381 @default.
• W932024246 cites W2065696973 @default.
• W932024246 cites W2074833892 @default.
• W932024246 cites W2085197080 @default.
• W932024246 cites W2085509575 @default.
• W932024246 cites W2092122739 @default.
• W932024246 cites W2093710180 @default.
• W932024246 cites W2096783955 @default.
• W932024246 cites W2114122851 @default.
• W932024246 cites W2116222318 @default.
• W932024246 cites W2116378614 @default.
• W932024246 cites W2170093022 @default.
• W932024246 cites W2321440179 @default.
• W932024246 cites W603324113 @default.
• W932024246 hasPublicationYear "2003" @default.
• W932024246 type Work @default.
• W932024246 sameAs 932024246 @default.
• W932024246 citedByCount "2" @default.
• W932024246 countsByYear W9320242462012 @default.
• W932024246 crossrefType "dissertation" @default.
• W932024246 hasAuthorship W932024246A5022871139 @default.
• W932024246 hasConcept C107872376 @default.
• W932024246 hasConcept C178790620 @default.
• W932024246 hasConcept C181199279 @default.
• W932024246 hasConcept C185592680 @default.
• W932024246 hasConcept C2780348204 @default.
• W932024246 hasConcept C2781005124 @default.
• W932024246 hasConcept C27881333 @default.
• W932024246 hasConcept C2909208804 @default.
• W932024246 hasConcept C31903555 @default.
• W932024246 hasConcept C505870484 @default.
• W932024246 hasConcept C55493867 @default.
• W932024246 hasConcept C62231903 @default.
• W932024246 hasConcept C71572567 @default.
• W932024246 hasConcept C86803240 @default.
• W932024246 hasConceptScore W932024246C107872376 @default.
• W932024246 hasConceptScore W932024246C178790620 @default.
• W932024246 hasConceptScore W932024246C181199279 @default.
• W932024246 hasConceptScore W932024246C185592680 @default.
• W932024246 hasConceptScore W932024246C2780348204 @default.
• W932024246 hasConceptScore W932024246C2781005124 @default.
• W932024246 hasConceptScore W932024246C27881333 @default.
• W932024246 hasConceptScore W932024246C2909208804 @default.
• W932024246 hasConceptScore W932024246C31903555 @default.
• W932024246 hasConceptScore W932024246C505870484 @default.
• W932024246 hasConceptScore W932024246C55493867 @default.
• W932024246 hasConceptScore W932024246C62231903 @default.
• W932024246 hasConceptScore W932024246C71572567 @default.
• W932024246 hasConceptScore W932024246C86803240 @default.
• W932024246 hasLocation W9320242461 @default.
• W932024246 hasOpenAccess W932024246 @default.
• W932024246 hasPrimaryLocation W9320242461 @default.
• W932024246 hasRelatedWork W2031807909 @default.
• W932024246 hasRelatedWork W2099578683 @default.
• W932024246 hasRelatedWork W2280111985 @default.
• W932024246 hasRelatedWork W2339864323 @default.
• W932024246 hasRelatedWork W2494274918 @default.
• W932024246 hasRelatedWork W2789956127 @default.
• W932024246 hasRelatedWork W2969359481 @default.
• W932024246 hasRelatedWork W3162938425 @default.
• W932024246 hasRelatedWork W3190090485 @default.
• W932024246 hasRelatedWork W2181809145 @default.
• W932024246 isParatext "false" @default.
• W932024246 isRetracted "false" @default.
• W932024246 magId "932024246" @default.
• W932024246 workType "dissertation" @default.