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- W932091708 abstract "Publisher Summary This chapter discusses the recent trends in the physiology of the posterior pituitary. Recent work has clarified some details of the mechanism of neurosecretion, although the precise nature of the process of release requires further investigation. The chapter also discusses two aspects of neurosecretion—the process by which the peptides are synthesized in the hypothalamus, and the process by which they are released into the circulation in response to stimuli. Oxytocin and vasopressin are synthesized in the form of a large precursor molecule, the nature and fate of which remains to be determined. It is possible that neurophysin is the precursor, and that it is released into the blood stream in parallel with the active peptides. In the circulation, neurophysin may have additional functions. These include binding of oxytocin and vasopressin; a separate but identified function of its own; or circulation of the intact precursor molecule with release at the target organ. Oxytocin has been relegated to a role in lactation and parturition. These events take up only a few hours in the life of most mammals, and none in the males of the species. It is possible that it may have other functions; prime among these would be a role in salt and water metabolism, if only because it so closely relates phylogenetically to vasopressin." @default.
- W932091708 created "2016-06-24" @default.
- W932091708 creator A5041831352 @default.
- W932091708 date "1971-01-01" @default.
- W932091708 modified "2023-09-25" @default.
- W932091708 title "Recent Trends in the Physiology of the Posterior Pituitary" @default.
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