FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W93224527> ?p ?o ?g. }

• W93224527 endingPage "7" @default.
• W93224527 startingPage "1231" @default.
• W93224527 abstract "The t(14;18) translocation, found in most human follicular non-Hodgkin's lymphomas (NHLs), juxtaposes the Bcl-2 oncogene at 18q21 with the immunoglobulin heavy chain locus at 14q32. As a result, the Bcl-2 protein is markedly overproduced. Most of the breakpoints on chromosome 18 cluster at one of two sites, the major breakpoint region (mbr) and the minor cluster region (mcr). Recently, others used the polymerase chain reaction (PCR) to detect the t(14;18) mbr in 32% of specimens diagnosed as Hodgkin's disease (HD). In an attempt to confirm and extend those observations the authors used PCR to assay for both the mbr and mcr in HD specimens diagnosed at their institution and examined the specimens for Bcl-2 overproduction. The authors subjected the DNAs from 28 well-characterized HD tumors of 26 patients to PCR analyses using primers specific for the t(14;18) mbr and mcr breakpoints. Based on various PCR controls, the authors ascertained that 26 of the 28 specimens contained amplifiable template DNA. Southern blotting of the amplification products showed that none of the 26 HD DNAs had detectable t(14;18) mbr or mcr breakpoints. By admixing small amounts of t(14;18)-bearing NHL DNA with HD DNA samples, the authors directly demonstrated that the sensitivity of the PCR assays was adequate for the molecular detection of t(14;18)-bearing cells at a frequency comparable to that of Reed-Sternberg cells and their variants in HD. Immunohistochemical studies employing a highly specific anti-Bcl-2 antiserum under conditions optimized to detect t(14;18)-mediated overexpression of the Bcl-2 gene showed that the Reed-Sternberg cells and variants in all 19 HD tumors examined were negative for Bcl-2 immunostaining. In conclusion, the PCR and immunohistochemical data provided evidence that the t(14;18) translocation was not involved in the pathogenesis of the HD cases." @default.
• W93224527 created "2016-06-24" @default.
• W93224527 creator A5005700015 @default.
• W93224527 creator A5035106895 @default.
• W93224527 creator A5059438505 @default.
• W93224527 creator A5090465788 @default.
• W93224527 date "1991-12-01" @default.
• W93224527 modified "2023-09-23" @default.
• W93224527 title "Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease." @default.
• W93224527 cites W112480256 @default.
• W93224527 cites W1568678893 @default.
• W93224527 cites W1898236813 @default.
• W93224527 cites W1949958721 @default.
• W93224527 cites W1971827703 @default.
• W93224527 cites W1999197294 @default.
• W93224527 cites W2008898220 @default.
• W93224527 cites W2016575124 @default.
• W93224527 cites W2060813712 @default.
• W93224527 cites W2075576299 @default.
• W93224527 cites W2083927509 @default.
• W93224527 cites W2089298737 @default.
• W93224527 cites W2096428903 @default.
• W93224527 cites W2102666057 @default.
• W93224527 cites W2122095304 @default.
• W93224527 cites W2137144638 @default.
• W93224527 cites W2156276815 @default.
• W93224527 cites W2165553878 @default.
• W93224527 cites W2255698332 @default.
• W93224527 cites W2322743884 @default.
• W93224527 cites W2330609930 @default.
• W93224527 cites W2332991185 @default.
• W93224527 cites W2397222521 @default.
• W93224527 cites W2403431328 @default.
• W93224527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886479" @default.
• W93224527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1750500" @default.
• W93224527 hasPublicationYear "1991" @default.
• W93224527 type Work @default.
• W93224527 sameAs 93224527 @default.
• W93224527 citedByCount "22" @default.
• W93224527 countsByYear W932245272013 @default.
• W93224527 crossrefType "journal-article" @default.
• W93224527 hasAuthorship W93224527A5005700015 @default.
• W93224527 hasAuthorship W93224527A5035106895 @default.
• W93224527 hasAuthorship W93224527A5059438505 @default.
• W93224527 hasAuthorship W93224527A5090465788 @default.
• W93224527 hasConcept C104317684 @default.
• W93224527 hasConcept C133307689 @default.
• W93224527 hasConcept C138626823 @default.
• W93224527 hasConcept C153911025 @default.
• W93224527 hasConcept C159654299 @default.
• W93224527 hasConcept C203014093 @default.
• W93224527 hasConcept C206936463 @default.
• W93224527 hasConcept C2779338263 @default.
• W93224527 hasConcept C2779390272 @default.
• W93224527 hasConcept C2781018059 @default.
• W93224527 hasConcept C29537977 @default.
• W93224527 hasConcept C2992779791 @default.
• W93224527 hasConcept C49105822 @default.
• W93224527 hasConcept C54355233 @default.
• W93224527 hasConcept C552990157 @default.
• W93224527 hasConcept C84597430 @default.
• W93224527 hasConcept C86803240 @default.
• W93224527 hasConcept C96007430 @default.
• W93224527 hasConceptScore W93224527C104317684 @default.
• W93224527 hasConceptScore W93224527C133307689 @default.
• W93224527 hasConceptScore W93224527C138626823 @default.
• W93224527 hasConceptScore W93224527C153911025 @default.
• W93224527 hasConceptScore W93224527C159654299 @default.
• W93224527 hasConceptScore W93224527C203014093 @default.
• W93224527 hasConceptScore W93224527C206936463 @default.
• W93224527 hasConceptScore W93224527C2779338263 @default.
• W93224527 hasConceptScore W93224527C2779390272 @default.
• W93224527 hasConceptScore W93224527C2781018059 @default.
• W93224527 hasConceptScore W93224527C29537977 @default.
• W93224527 hasConceptScore W93224527C2992779791 @default.
• W93224527 hasConceptScore W93224527C49105822 @default.
• W93224527 hasConceptScore W93224527C54355233 @default.
• W93224527 hasConceptScore W93224527C552990157 @default.
• W93224527 hasConceptScore W93224527C84597430 @default.
• W93224527 hasConceptScore W93224527C86803240 @default.
• W93224527 hasConceptScore W93224527C96007430 @default.
• W93224527 hasIssue "6" @default.
• W93224527 hasLocation W932245271 @default.
• W93224527 hasOpenAccess W93224527 @default.
• W93224527 hasPrimaryLocation W932245271 @default.
• W93224527 hasRelatedWork W1537080926 @default.
• W93224527 hasRelatedWork W1969849716 @default.
• W93224527 hasRelatedWork W2013898255 @default.
• W93224527 hasRelatedWork W2046607403 @default.
• W93224527 hasRelatedWork W2059754755 @default.
• W93224527 hasRelatedWork W2065138021 @default.
• W93224527 hasRelatedWork W2100395226 @default.
• W93224527 hasRelatedWork W2256681326 @default.
• W93224527 hasRelatedWork W2561063563 @default.
• W93224527 hasRelatedWork W2559046844 @default.
• W93224527 hasVolume "139" @default.
• W93224527 isParatext "false" @default.
• W93224527 isRetracted "false" @default.

• next