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- W93226469 abstract "THE toxic effects of silica particles on cultured mouse macrophages have been studied by phase-contrast cinemicrography, electron microscopy and histochemical techniques for lysosomal enzymes. Both silica and non-toxic particles (aluminiumcoated silica, amorphous carbon and diamond dust) were taken up into phagosomes in the cytoplasm. Lysosomes adhered to the phagosomal membranes and discharged their enzymes into the phagosomes. However, non-toxic particles and lysosomal enzymes remained confined within the phagosomal membranes for at least 4 days, whereas within 24 hr there was escape of silica and lysosomal enzymes into the cytoplasm. This was associated with rounding and loss of mobility of the macrophages, rapidly followed by cell death as judged by permeability of the cell membranes to eosin. It is concluded that silicic acid reacts with and makes permeable the phagosomal membranes, releasing the hydrolytic enzymes into the cytoplasm. Polyvinyl-pyridine-iV-oxide prevents this by preferentially forming hydrogen bonds with silicic acid" @default.
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- W93226469 date "1967-01-01" @default.
- W93226469 modified "2023-10-15" @default.
- W93226469 title "OBSERVATIONS ON THE CYTOTOXIC ACTION OF SILICA ON MACROPHAGES" @default.
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- W93226469 doi "https://doi.org/10.1016/b978-1-4832-1329-3.50018-4" @default.
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