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- W93264420 abstract "Treatment of human placenta microsomes with phospholipase A or D inhibits the 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity, parallel with the hydrolysis of membrane phospholipids. The 17beta-HSD activity of phospholipase treated microsomes is reactivated by synthetic phospholipids. The distribution of 17beta-HSD activity in subfractions of original microsomes and of phospholipase treated microsomes obtained by zonal centrifugation was studied. Solubilization of the microsomal 17beta-HSD was achieved by phospholipase A treatment. Two 17beta-HSD were solubilized from human placenta microsomes by phospholipase A treatment and were further purified by ammonium sulphate precipitation, gel filtration on BioGel A-0.5 m, DEAE-Sephadex chromatography and by isoelectric focusing. The enzymes were purified 25.8 and 17.4 times. The isoelectric points and molecular weights of the two 17beta-HSD were determined. Both enzymes are of a 17beta-HSD type. One of the 17beta-HSD, however, was sensitive to estradiol-17beta, the other to testosterone. The question of whether the two enzymes constitute a monomer and a dimer of the same 17beta-HSD or are completely different enzymes, is discussed." @default.
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- W93264420 date "1975-01-01" @default.
- W93264420 modified "2023-09-23" @default.
- W93264420 title "[Microsome-associated 17 beta-hydroxysteroid dehydrogenases of human placenta, i solubilization, enrichment and separation of two 17 beta-hsd-activities after phospholipase-Treatment]." @default.
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