FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W932754170> ?p ?o ?g. }

• W932754170 endingPage "10172" @default.
• W932754170 startingPage "10165" @default.
• W932754170 abstract "Extraction of petrochemicals from the surface mining of oil sand deposits results in generation of large volumes of oil sands process-affected water (OSPW). Naphthenic acids (NA) are generally considered to be among the most toxic components of OSPW. Previous studies have shown that NAs are toxic to aquatic organisms, however knowledge of their effects on mammalian health and development is limited. In the present study, we evaluated the developmental effects of an NA extract prepared from fresh OSPW on differentiating mouse embryonic stem cells (ESC). We found that treatment of differentiating cells with the NA extract at noncytotoxic concentrations alters expression of various lineage specification markers and development of the heart. Notably, expression of cardiac specific markers such as Nkx2.5, Gata4, and Mef2c were significantly up-regulated. Moreover, exposure to the NA extract enhanced differentiation of embryoid bodies and resulted in the early appearance of spontaneously beating clusters. Interestingly, exposure of undifferentiated mouse ESCs to the NA extract did not change the expression level of pluripotency markers (i.e., Oct4, Nanog, and Sox2). Altogether, these data identify some of the molecular pathways affected by components within this NA extract during differentiation of mammalian cells." @default.
• W932754170 created "2016-06-24" @default.
• W932754170 creator A5010140238 @default.
• W932754170 creator A5040886240 @default.
• W932754170 creator A5044076528 @default.
• W932754170 creator A5053873110 @default.
• W932754170 creator A5062900356 @default.
• W932754170 creator A5078923324 @default.
• W932754170 date "2015-08-07" @default.
• W932754170 modified "2023-10-17" @default.
• W932754170 title "Naphthenic Acid Mixtures from Oil Sands Process-Affected Water Enhance Differentiation of Mouse Embryonic Stem Cells and Affect Development of the Heart" @default.
• W932754170 cites W1520523096 @default.
• W932754170 cites W1968784287 @default.
• W932754170 cites W1979640013 @default.
• W932754170 cites W1985716327 @default.
• W932754170 cites W1986813124 @default.
• W932754170 cites W1988342449 @default.
• W932754170 cites W1990131329 @default.
• W932754170 cites W1990374976 @default.
• W932754170 cites W1999866312 @default.
• W932754170 cites W2014315939 @default.
• W932754170 cites W2024765404 @default.
• W932754170 cites W2027698076 @default.
• W932754170 cites W2031020821 @default.
• W932754170 cites W2031731336 @default.
• W932754170 cites W2035595297 @default.
• W932754170 cites W2045400589 @default.
• W932754170 cites W2074779874 @default.
• W932754170 cites W2076410084 @default.
• W932754170 cites W2077206928 @default.
• W932754170 cites W2079344786 @default.
• W932754170 cites W2094671653 @default.
• W932754170 cites W2107277218 @default.
• W932754170 cites W2109622975 @default.
• W932754170 cites W2113416822 @default.
• W932754170 cites W2118847235 @default.
• W932754170 cites W2133793464 @default.
• W932754170 cites W2140691687 @default.
• W932754170 cites W2142763550 @default.
• W932754170 cites W2148454982 @default.
• W932754170 cites W2163326928 @default.
• W932754170 cites W2168087907 @default.
• W932754170 doi "https://doi.org/10.1021/acs.est.5b02267" @default.
• W932754170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26182351" @default.
• W932754170 hasPublicationYear "2015" @default.
• W932754170 type Work @default.
• W932754170 sameAs 932754170 @default.
• W932754170 citedByCount "18" @default.
• W932754170 countsByYear W9327541702016 @default.
• W932754170 countsByYear W9327541702017 @default.
• W932754170 countsByYear W9327541702018 @default.
• W932754170 countsByYear W9327541702019 @default.
• W932754170 countsByYear W9327541702020 @default.
• W932754170 countsByYear W9327541702021 @default.
• W932754170 countsByYear W9327541702023 @default.
• W932754170 crossrefType "journal-article" @default.
• W932754170 hasAuthorship W932754170A5010140238 @default.
• W932754170 hasAuthorship W932754170A5040886240 @default.
• W932754170 hasAuthorship W932754170A5044076528 @default.
• W932754170 hasAuthorship W932754170A5053873110 @default.
• W932754170 hasAuthorship W932754170A5062900356 @default.
• W932754170 hasAuthorship W932754170A5078923324 @default.
• W932754170 hasConcept C104317684 @default.
• W932754170 hasConcept C107459253 @default.
• W932754170 hasConcept C143948831 @default.
• W932754170 hasConcept C145103041 @default.
• W932754170 hasConcept C185592680 @default.
• W932754170 hasConcept C207701140 @default.
• W932754170 hasConcept C2777933648 @default.
• W932754170 hasConcept C28328180 @default.
• W932754170 hasConcept C43617362 @default.
• W932754170 hasConcept C4725764 @default.
• W932754170 hasConcept C55493867 @default.
• W932754170 hasConcept C86803240 @default.
• W932754170 hasConcept C95444343 @default.
• W932754170 hasConceptScore W932754170C104317684 @default.
• W932754170 hasConceptScore W932754170C107459253 @default.
• W932754170 hasConceptScore W932754170C143948831 @default.
• W932754170 hasConceptScore W932754170C145103041 @default.
• W932754170 hasConceptScore W932754170C185592680 @default.
• W932754170 hasConceptScore W932754170C207701140 @default.
• W932754170 hasConceptScore W932754170C2777933648 @default.
• W932754170 hasConceptScore W932754170C28328180 @default.
• W932754170 hasConceptScore W932754170C43617362 @default.
• W932754170 hasConceptScore W932754170C4725764 @default.
• W932754170 hasConceptScore W932754170C55493867 @default.
• W932754170 hasConceptScore W932754170C86803240 @default.
• W932754170 hasConceptScore W932754170C95444343 @default.
• W932754170 hasIssue "16" @default.
• W932754170 hasLocation W9327541701 @default.
• W932754170 hasLocation W9327541702 @default.
• W932754170 hasOpenAccess W932754170 @default.
• W932754170 hasPrimaryLocation W9327541701 @default.
• W932754170 hasRelatedWork W1597633061 @default.
• W932754170 hasRelatedWork W2058675403 @default.
• W932754170 hasRelatedWork W2335409602 @default.
• W932754170 hasRelatedWork W2391145039 @default.
• W932754170 hasRelatedWork W2517286276 @default.

• next