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• W9331374 abstract "Absolute and relative values of lymphocyte classes in peripheral blood of 19 to 80 year-old, apparently healthy donors were determined simultaneously by means of the cytocentrifuge method. Lymphocytes were classed as cells which formed rosettes with neuraminidase-treated sheep erythrocytes (T cells), as cells which bound C3b-loaded zymosan particles (B cells), or those which showed both characteristics (doubly marked cells = D cells). Cells which exhibited none of the above characteristics were classed as 0 cells. The reproducible absolute values of T, B, D, and 0 cells showed a statistically significant decline with age, similarly to a decline in the total lymphocyte counts. The relative values in per cent, however, remained constant over the whole age spectrum. In 1 hour experiments, the acid phosphatase activity of non-stimulated and of PHA-P-stimulated cells decreased with age, the latter, however, less than did the controls. Therefore, the stimulating effect increased significantly. When cells were stimulated for a period of 4 hours, the stimulating effect decreased with age, indicating an age-dependent loss of longer lasting reactivity to PHA-P controlled by acid phosphatase activity." @default.
• W9331374 created "2016-06-24" @default.
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• W9331374 date "1977-07-01" @default.
• W9331374 modified "2023-09-26" @default.
• W9331374 title "Variation of Lymphocyte Classes and their PHA-P Reactivity with Age" @default.
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• W9331374 doi "https://doi.org/10.1016/s0340-904x(77)80044-4" @default.
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