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- W93326188 abstract "ABSTRACT Directed selection procedures using rational prescreening methodology based on known genetic and biochemical mechanisms have been reported to be successful for many established fermentation organisms and now have largely replaced the empirical mutation and selection procedures. The following techniques have been successful for a variety of producer organisms: (1) direct selection of colonies following plate overlay bioassay; (2) use of analogue-resistant mutants which overproduce rate-limiting biosynthetic intermediates; (3) isolation of mutants resistant to metallic ions which complex antibiotic molecules; (4) selection of auxotrophs followed by reversion to prototrophy; (5) selection of mutants resistant to toxic precursor molecules or to toxic levels of end-product; (6) isolation of desirable morphological types; (7) use of stable recombinant strains and (8) isolation of strains following exposure to agents inducing higher ploidy or compounds known to eliminate chromosomal aberrations. The recent rapid advances in protoplast fusion and recombinant DNA technology now allow the microbial geneticist to perform gene transfer and subsequent amplification in organisms in which the genetics and biochemistry are much better understood, i.e., Escherichia coli , Bacillus subtilis , Streptomyces coelicolor , Saccharomyces cerevisiae , etc. The new technologies will culminate in the generation of new highly productive recombinant strains capable of producing novel useful metabolites." @default.
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- W93326188 date "1981-01-01" @default.
- W93326188 modified "2023-09-27" @default.
- W93326188 title "STRAIN IMPROVEMENT PROGRAMS IN ANTIBIOTIC-PRODUCING MICROORGANISMS - PRESENT AND FUTURE STRATEGIES" @default.
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- W93326188 doi "https://doi.org/10.1016/b978-0-08-025383-1.50008-4" @default.
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