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W933298368 abstract "OBJECTIVE: The purpose of this study is to evaluate the usefullness of FDG PET in early identification of aortitis in patients with Takayasu arteritis presented as young stroke. BACKGROUND: Takayasu’s arteritis is a chronic granulomatous, primary vasculitis affecting large vessels with 10[percnt] of the people present as young stroke. Clinically Aymmetric pulse made us suspect takayasu and Diagnosis made by angiography which is gold standard. More recently, vascular FDG-PET is emerging tool for vascular inflammation. DESIGN/METHODS: Total of 9 patients with young stroke having takayasu arteritis diagnosed according to American college of rheumatology criteria . Six patients with Takayasu arteritis in the active stage(showing elevated level of general inflammatory markers), 3 patients with Takayasu arteritis in the inactive stage, underwent FDG-PET and the inﬂammatory vascular lesion was evaluated by using the standardized uptake value (SUV) of FDG accumulation as an index. Patient were treated with steroids/immunomodulators and a follow up FDG PET done after 1 month to monitor treatment response. RESULTS: The FDG PET revealed intense FDG accumulation (SUV > 2.7) in the vasculature of 4 cases in the active stage of Takayasu arteritis. The other 2 patients in the active stage revealed weak FDG accumulation (2.3 > SUV < 1.2). No signiﬁcant FDG accumulation was observed in the patients with inactive disease (SUV < 1.2). Given the cutoff SUV is 1.3, the sensitivity of FDG PET analysis of Takayasu arteritis is 66.67[percnt]. Finally, FDG accumulation resolved with therapy in 6 active cases. CONCLUSIONS: The FDG PET images in Takayasu helps in early detection, evaluate the disease extent, grading based on the standardized uptake value and idealy to monitor the treatment response. Disclosure: Dr. SHANKAR has nothing to disclose. Dr. Kalaimani has nothing to disclose. Dr. Lakshmi Narasimhan has nothing to disclose. Dr. Srinivasan Raman has nothing to disclose. Dr. Kesavamurthy has nothing to disclose." @default.
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W933298368 date "2015-04-06" @default.
W933298368 modified "2023-09-26" @default.
W933298368 title "FDG-PET As A Radiological Biomarker In Patients With Takayasu Arteritis (P2.292)" @default.
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