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- W93334254 abstract "This chapter describes the influence of the chemical structure of spin-labeled organophosphates on the inhibition and reactivation of acetylcholinesterase. Spin-labeled organophosphates with different alkyl chain length were synthesized to examine the microgeography of acetylcholinesterase. The chapter discusses the inhibitory activity and the influence of pyridine-2-aldoxime methoidide on the phosphorilated enzyme were studied with regard to the structure of the spin label used. The inhibition and reactivation of the enzyme activity was determined by measuring the enzyme activity at pH 7.4 as well as by measuring the intensity of the EPR spectra. Results obtained by both methods are in quite a good correlation. The EPR method can also be used as an analytical method for the estimation of the reactivation. The percentage of inhibition and reactivation as well as biomolecular constants for the inhibition of the enzyme depends on the number of C atoms in the alkyl chain. They normally decrease with the increasing chain length, if the even-odd phenomenon is taken into account. Substances with an even number of C atoms in the alkyl chain are less active than those with an odd number and can hardly be reactivated." @default.
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- W93334254 date "1980-01-01" @default.
- W93334254 modified "2023-10-16" @default.
- W93334254 title "INFLUENCE OF THE CHEMICAL STRUCTURE OF SPIN LABELED ORGANOPHOSPHATES ON THE INHIBITION AND REACTIVATION OF ACETYLCHOLINESTERASE" @default.
- W93334254 doi "https://doi.org/10.1016/b978-0-08-025921-5.50219-8" @default.
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