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- W93367465 abstract "ABSTRACT Blockade of impulse traffic in the nigrostriatal pathway by axotomy causes a rise in striatal dopamine and activation of tyrosine hydroxylase in adult and 10 day old rats. These responses do not occur in 4 day old rats. Moreover, while α -methyl-p-tyrosine causes a loss of DA at both ages, the loss at 10 days, but not at 4 days, is blocked by axotomy. These results suggest there is little impulse traffic at 4 days of age. However, impulse traffic can be initiated by haloperidol and tyrosine hydroxylase activated by γ-OH-butyrate at both ages. Thus, while functionally competent at 4 days, the dopamine neurons are not physiologically active at this age." @default.
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- W93367465 date "1979-01-01" @default.
- W93367465 modified "2023-09-28" @default.
- W93367465 title "FUNCTIONAL DEVELOPMENT OF THE DOPAMINERGIC NIGROSTRIATAL SYSTEM" @default.
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- W93367465 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50245-7" @default.
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