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- W93379968 abstract "Abstract Dynamics of cell-surface proteins are strongly influenced by their localized interactions with cytoskeletal attachments or intracellular signaling molecules. We developed a technique to analyze single particle trajectories to quantify these interactions. We modeled trajectories of a cell membrane-associated protein interacting with a homogeneously distributed binding partner, and applied this model to analyze the motion of the integrin receptor LFA-1 on the surface of T cells. Our analysis reveals that the diffusion of LFA-1 is two-state, with distinct diffusion coefficients in its free and cytoskeleton-bound forms. We also quantify the rates of transition between the two states, and we show that cellular activation leads to large changes in the LFA-1-cytoskeleton interactions." @default.
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- W93379968 date "2009-04-01" @default.
- W93379968 modified "2023-10-16" @default.
- W93379968 title "A novel analysis of single particle trajectories quantifies the dynamic interactions between LFA-1 and the actin cytoskeleton (94.13)" @default.
- W93379968 doi "https://doi.org/10.4049/jimmunol.182.supp.94.13" @default.
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