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- W934131708 abstract "This chapter discusses the extracellular space of the brain. Some 10–15 % of the volume of the brain behaves as though it were extracellular, in the sense that under appropriate conditions an extracellular “tag,” such as sucrose, will come into equilibrium with it. The appropriate condition is that the sucrose should be presented by a non-vascular route so that the blood-brain barrier has been circumvented. In the chapter, quantitative aspects of this space are discussed and the problem as to why it is inaccessible to extracellular tags when given by the vascular route is considered. It is suggested that there are two extracellular spaces: a very small one between the blood vessels and their glial covering and a larger one representing the spaces among the tissue cells generally; it is this latter space that is inaccessible to intravascularly administered extracellular tags, by virtue of the low permeability of the glial coating of the capillaries. It seems likely from recent studies of the exchange of ions between cerebrospinal fluid and brain that the composition of this latter space is controlled by secretory processes." @default.
- W934131708 created "2016-06-24" @default.
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- W934131708 date "1965-01-01" @default.
- W934131708 modified "2023-10-16" @default.
- W934131708 title "The Extracellular Space of the Brain" @default.
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- W934131708 doi "https://doi.org/10.1016/s0079-6123(08)60943-7" @default.
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