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- W93415217 abstract "目的探讨在人类Jurkat系T肿瘤细胞内，不同浓度的过氧化物酶体增生物激活受体γ（PPAR-γ）配体对一氧化氮合酶（NOS）活性的影响及意义。方法Jurkat系T淋巴肿瘤细胞随机分为对照组和1，5，10，15，20μmol／L罗格列酮实验组，对照组不加药物，每组设5个重复，培养12h后用一氧化氮合酶测定试剂盒检测细胞裂解液中NOS活性，RT—PCR法检测T肿瘤细胞PPAR-γmRNA表达情况。结果PPAR-γmRNA逆转录产物的含量随着用药浓度的增大而依次升高，各实验组用药12h后的NOS活性均显著高于对照组NOS的活性[（0．415±0．075）U／mLvs（0．552±0．056）U／mL，（0．402±0，08）U／mLvs（0．643±0．036）U／mL，（0．429±0．046）U／mL vs（0．716±0．026）U／mL，（0．443±0．026）U／mLvs（0．749±0．038）U／mL，（0．431±0．04）U／mLvs（0．861±0．013）U／mL，P〈0．05]，且PPAR-γ mRNA逆转录产物的含量与NOS活性呈正相关（r=0．918，P〈0．05）。结论在Jurkat系T肿瘤细胞内，PPAR-γ活化剂能够以浓度依赖的形式增加NOS活性，PPAR-γ可能通过NOS途径来发挥相应的抗瘤作用．" @default.
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- W93415217 date "2009-01-01" @default.
- W93415217 modified "2023-09-24" @default.
- W93415217 title "PPAR-γ配体对Jurkat T淋巴瘤细胞NOS活性的影响" @default.
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