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• W934403744 abstract "Ovalis sejtes reakcio indulasakor a patkany majaban sajatos fenotipusu CK19+/7- ductulusok hamsejtjei kezdenek proliferalni. Ez alapjan arra lehet kovetkeztetni, hogy a maj őssejtek ebben a kompartmentben talalhatoak. A CK19+/7- ductulusok hosszu, olykor elagazodo kepleteket alkotnak, melyek nem terjednek be a hepatocytak koze. Ez a sajatos epeut fenotipus csak postnatalisan alakul ki. Az ovalis sejtek tobbfele megoszlasban is kepesek hepatocytakka differencialodni, de cellularis szinten a differencialodasi program azonosnak tűnik. A folyamat HNF4 expresszioval es a bazalis membran degradalodasaval kezdődik, amit gyorsan kovet az epeut markerek (OV6,Cx43, integrin 1) eltűnese, a hepatocyta tulajdonsagok (CYP, CD26, Cx32, integrin 1) megjelenese. A differencialodas folyamata felgyorsithato hepatocyta mitogenekkel. Az ezt kovető regeneracio szerum szinten is javulo majfunkcioval jar kiserleti allatokban. Csontvelő sejtekből nem sikerult transzdifferencialodas utjan hepatocytakat előallitanunk. Eredmenyeink szerint az ovalis sejteken leirt haemopoetikus marker (Thy-1) is valojaban az ovalis sejtekkel szoros kontaktusban levő stellat sejtekben expresszalodik. A majukban fokozott mertekben TGF-t termelő transzgen egerekben a tioacetamid indukalt majfibrosis felgyorsulasa a regresszio lelassulasa volt megfigyelhető. | There are biliary ductules in the rat liver with a unique CK19+/7- phenotype. This special immunophenotype develops only in the postnatal life These are the ductules which are proliferating first at the beginning of oval cell proliferation, indicating that they may harbour the hepatic stem cell compartment. These ductules, contrary to the traditional view of canals of Hering form occasionally long, winding and branching tubules but they do not spread into the liver lobule. The oval cells are able to differentiate into hepatocytes in different distributions. But the differentiation program on cellular level seems identical. The process is initiated by the upregulation of HNF-4 and the degradation of the basement membrane. This is followed by the disappearance of biliary markers (e.g. OV6,Cx43, 6 integrin) and expression of hepatocytic markers (CYP enzymes, Cx32, 1 integrin, CD26). The differentiation can be accelerated by primary hepatocyte mitogens. The improved hepatic function can be detected after the differentiation even in the serum of the animals. We did not succeed to generate hepatocytes from bone marrow cells by transdifferentiation. We also studied the expression of a haemopoetic stem cell marker, Thy-1 in our oval cell proliferation model and found it to be present not on the oval cells, as it had been reported, but on the stellate cells. Accelerated liver fibrosis and decelerated regression was observed following thioacetamide treatment in transgenic mice overexpressing TGF-beta in their liver." @default.
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• W934403744 date "2007-01-01" @default.
• W934403744 modified "2023-09-23" @default.
• W934403744 title "Az őssejtek részvétele a máj regenerációban és a carcinogenezisben = The role of stem cells in liver regeneration and carcinogenesis" @default.
• W934403744 hasPublicationYear "2007" @default.
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