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• W93441401 abstract "Gene delivery with a physical mechanism using ultrasound (US) and nano/microbubbles is expected as an ideal system in terms of delivering plasmid DNA noninvasively into a specific target site. We developed novel liposomal bubbles (Bubble liposomes (BLs)) containing the lipid nanobubbles of perfluoropropane which were utilized for contrast enhancement in ultrasonography. BLs were smaller in diameter than conventional microbubbles and induced cavitation upon exposure ultrasound. In addition, when coupled with US exposure, BLs could deliver plasmid DNA into various types of cells in vitro and in vivo. The transfection efficiency with BLs and US was higher than that with conventional lipofection method. Therefore, the combination of BLs and US might be an efficient and novel nonviral gene delivery system." @default.
• W93441401 created "2016-06-24" @default.
• W93441401 creator A5032796186 @default.
• W93441401 creator A5045164231 @default.
• W93441401 date "2009-11-21" @default.
• W93441401 modified "2023-09-24" @default.
• W93441401 title "Effective In Vitro and In Vivo Gene Delivery by the Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound Exposure" @default.
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• W93441401 doi "https://doi.org/10.1007/978-1-60327-360-2_33" @default.
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