Matches in SemOpenAlex for { <https://semopenalex.org/work/W93443406> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W93443406 endingPage "307" @default.
- W93443406 startingPage "297" @default.
- W93443406 abstract "In view of the clear documentation that T-cell function in the acquired immunodefiency syndrome (AIDS) is grossly impaired, the striking susceptibility of AIDS patients to infections caused by intracellular micro-organisms is not only not surprising but is predictable. Indeed, if one draws up a list of the pathogens against which successful host defense is thought to require an intact cell-mediated immune response (1) and compares this to a list of the pathogens which regularly infect patients with AIDS (2) (Table 1), the two lists are virtually superimposable. In addition, many of the AIDS pathogens are known to be intracellular organisms which, although capable of causing quite different clinical manifestations, share the common feature of being able to enter and replicate within unstimulated macrophages (1). In the presence of a normal, effective T cell-dependent immune response, however, presumed to be largely mediated by antigen-triggered lymphokine secretion with resultant macrophage activation, these same intracellular pathogens are killed or their growth is inhibited. Thus, the particular spectrum of opportunistic micro-organisms which consistently infect AIDS patients, the frequent failure of these patients to respond to appropriate antimicrobial therapy, their propensity for relapse despite adequate treatment, and the eventual uniformly fatal outcome of these infections all serve to graphically indicate that the process of macrophage activation in patients with AIDS is either profoundly disordered or more likely, has not taken place at all (3). Histopathologically, these clinical observations are expressed by the absence of granuloma formation, little or no inflammatory cell infiltrates, and overwhelming numbers of micro-organisms in wide-spread and numerous foci of tissue infection." @default.
- W93443406 created "2016-06-24" @default.
- W93443406 creator A5020235374 @default.
- W93443406 date "1988-01-01" @default.
- W93443406 modified "2023-09-27" @default.
- W93443406 title "Macrophage Activation in the Acquired Immunodeficiency Syndrome" @default.
- W93443406 cites W1543251537 @default.
- W93443406 cites W1551296796 @default.
- W93443406 cites W1599436637 @default.
- W93443406 cites W1812003287 @default.
- W93443406 cites W2163498187 @default.
- W93443406 doi "https://doi.org/10.1007/978-1-4757-5421-6_30" @default.
- W93443406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3059771" @default.
- W93443406 hasPublicationYear "1988" @default.
- W93443406 type Work @default.
- W93443406 sameAs 93443406 @default.
- W93443406 citedByCount "7" @default.
- W93443406 crossrefType "book-chapter" @default.
- W93443406 hasAuthorship W93443406A5020235374 @default.
- W93443406 hasConcept C126322002 @default.
- W93443406 hasConcept C147483822 @default.
- W93443406 hasConcept C153726182 @default.
- W93443406 hasConcept C202751555 @default.
- W93443406 hasConcept C203014093 @default.
- W93443406 hasConcept C2777607303 @default.
- W93443406 hasConcept C2779244956 @default.
- W93443406 hasConcept C49039625 @default.
- W93443406 hasConcept C49382859 @default.
- W93443406 hasConcept C54355233 @default.
- W93443406 hasConcept C71924100 @default.
- W93443406 hasConcept C79879829 @default.
- W93443406 hasConcept C86803240 @default.
- W93443406 hasConcept C8891405 @default.
- W93443406 hasConcept C95444343 @default.
- W93443406 hasConceptScore W93443406C126322002 @default.
- W93443406 hasConceptScore W93443406C147483822 @default.
- W93443406 hasConceptScore W93443406C153726182 @default.
- W93443406 hasConceptScore W93443406C202751555 @default.
- W93443406 hasConceptScore W93443406C203014093 @default.
- W93443406 hasConceptScore W93443406C2777607303 @default.
- W93443406 hasConceptScore W93443406C2779244956 @default.
- W93443406 hasConceptScore W93443406C49039625 @default.
- W93443406 hasConceptScore W93443406C49382859 @default.
- W93443406 hasConceptScore W93443406C54355233 @default.
- W93443406 hasConceptScore W93443406C71924100 @default.
- W93443406 hasConceptScore W93443406C79879829 @default.
- W93443406 hasConceptScore W93443406C86803240 @default.
- W93443406 hasConceptScore W93443406C8891405 @default.
- W93443406 hasConceptScore W93443406C95444343 @default.
- W93443406 hasLocation W934434061 @default.
- W93443406 hasLocation W934434062 @default.
- W93443406 hasOpenAccess W93443406 @default.
- W93443406 hasPrimaryLocation W934434061 @default.
- W93443406 hasRelatedWork W1519040467 @default.
- W93443406 hasRelatedWork W1562758188 @default.
- W93443406 hasRelatedWork W2037337415 @default.
- W93443406 hasRelatedWork W2037764050 @default.
- W93443406 hasRelatedWork W2040312602 @default.
- W93443406 hasRelatedWork W2117793283 @default.
- W93443406 hasRelatedWork W2171611230 @default.
- W93443406 hasRelatedWork W2176629742 @default.
- W93443406 hasRelatedWork W2220102944 @default.
- W93443406 hasRelatedWork W2414531686 @default.
- W93443406 isParatext "false" @default.
- W93443406 isRetracted "false" @default.
- W93443406 magId "93443406" @default.
- W93443406 workType "book-chapter" @default.