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- W934898843 abstract "Leishmania tropica is an obligate intracellular parasite of macrophages which causes cutaneous leishmaniasis in man. Infections in BALB/c mice with this parasite are characterized by the development of large primary ulcers and multiple non-healing metastatic cutaneous lesions (1,2,3). To date, the immunological mechanisms responsible for the inability of BALB/c mice to resolve leishmanial infections are unknown; however, specific suppressor T cells responsible for regulating skin test responses to leishmanial antigens have been reported (3,4). In addition, BALB/c mice infected with L. tropica develop a non-specific immunodepression, as described in this report. This immunodepression is mediated by an adherent suppressor cell which suppresses mitogen and leishmanial antigen responses in a lymphocyte transformation assay." @default.
- W934898843 created "2016-06-24" @default.
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- W934898843 date "1983-01-01" @default.
- W934898843 modified "2023-09-27" @default.
- W934898843 title "Immunodepression in BALB/c Mice Infected with Leishmania Tropica" @default.
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- W934898843 doi "https://doi.org/10.1007/978-1-4684-4481-0_15" @default.
- W934898843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6869088" @default.
- W934898843 hasPublicationYear "1983" @default.
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