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- W935211037 abstract "Abstract Because most autoimmune diseases exist in the periphery, we investigated whether MHC class I restricted TCRs could be used to re-direct expanded human Tregs in order to better target engineered Tregs to the site of the aberrant immune response. By taking advantage of a series of HLA-A2 restricted TCRs that recognize the same peptide-MHC class I (pMHC) with varying affinities, we observed augmenting TCR affinity had no effect on the ability of Tregs to function. In fact, MHC class I restricted TCRs that had limited activity in CD4+ T effector cells (Teff) were fully able to suppress the expansion of highly functional CD8 T cells expressing a high affinity TCR. These studies demonstrate that Tregs expressing naturally occurring, introduced MHC class I restricted TCRs have potent suppressive activity and further highlight the fundamental differences that exist between effector and regulatory T cells." @default.
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- W935211037 date "2011-04-01" @default.
- W935211037 modified "2023-09-25" @default.
- W935211037 title "Naturally occurring MHC class I restricted TCRs effectively redirect human T regulatory cells to suppress high affinity, polyfunctional CD8 T cell responses (52.8)" @default.
- W935211037 doi "https://doi.org/10.4049/jimmunol.186.supp.52.8" @default.
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